Bacteriophage λ int protein may recognizestructural features of the attachment sites

Ruth Nussinov, Robert A. Weisberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The bacteriophage λ int protein binds to and promotes polynucleotide strand exchange within specific DNA segments called attachment sites. Previous work strongly suggests that the specificity of int protein action is based, at least in part, on its ability to recognize nucleotide sequences in the attachment sites. We suggest that int protein also recognizes structural features of the attachment sites such as the twist and roll angles between adjacent base pairs. This proposal is based on statistical analysis of the predicted twist and roll angles of a large collection of secondary attachment sites. The analysis shows that the oscillation patterns of these parameters are conserved in regions where int proteins binds.

Original languageEnglish
Pages (from-to)1133-1144
Number of pages12
JournalJournal of Biomolecular Structure and Dynamics
Issue number6
StatePublished - Jun 1986


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