TY - JOUR
T1 - Bacterial cooperative organization under antibiotic stress
AU - Ben-Jacob, Eshel
AU - Cohen, Inon
AU - Golding, Ido
AU - Gutnick, David L.
AU - Tcherpakov, Marianna
AU - Helbing, Dirk
AU - Ron, Ilan G.
N1 - Funding Information:
We are grateful to Inna Brainis and Rina Avigad for technical assistance and to Amikam Shoob for photography of the colonies. This research has been partially supported by a grant from the Israeli Academy of Sciences, grant no. 461/98, by the Israeli–US Binational Science Foundation BSF, grant no. 00410-95, by a grant from IMK Almene Foundation, by the Deutsche Forschungsgemeinschaft (DFG, Heisenberg scholarship He 2789/1-1), and by The Milo and Shoshana Shefler Project.
PY - 2000/7/1
Y1 - 2000/7/1
N2 - Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the effect of antibiotic stress on the colonial development of Paenibacillus dendritiformis and P. vortex. We focus on the effect of co-trimoxazole on the colonial organization of P. dendritiformis. We find that the exposure to non-lethal concentrations of antibiotic leads to dramatic changes in the colonial growth patterns. Branching, tip-splitting patterns are affected by reduction in the colonial fractal dimension from Df = 2.0 to 1.7, appearance of pronounced weak chirality and pronounced radial orientation of the growth. We combine the experimental observations with numerical studies of both discrete and continuous generic models to reveal the causes for the modifications in the patterns. We conclude that the bacteria adjust their chemotactic signaling together with variations in the bacteria length and increase in the metabolic load.
AB - Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the effect of antibiotic stress on the colonial development of Paenibacillus dendritiformis and P. vortex. We focus on the effect of co-trimoxazole on the colonial organization of P. dendritiformis. We find that the exposure to non-lethal concentrations of antibiotic leads to dramatic changes in the colonial growth patterns. Branching, tip-splitting patterns are affected by reduction in the colonial fractal dimension from Df = 2.0 to 1.7, appearance of pronounced weak chirality and pronounced radial orientation of the growth. We combine the experimental observations with numerical studies of both discrete and continuous generic models to reveal the causes for the modifications in the patterns. We conclude that the bacteria adjust their chemotactic signaling together with variations in the bacteria length and increase in the metabolic load.
UR - http://www.scopus.com/inward/record.url?scp=0033704264&partnerID=8YFLogxK
U2 - 10.1016/S0378-4371(00)00093-5
DO - 10.1016/S0378-4371(00)00093-5
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AN - SCOPUS:0033704264
SN - 0378-4371
VL - 282
SP - 247
EP - 282
JO - Physica A: Statistical Mechanics and its Applications
JF - Physica A: Statistical Mechanics and its Applications
IS - 1
ER -