TY - JOUR
T1 - BAC consensus conference, November 4-6, 2004
T2 - Epidemiology, pathogenesis, and preclinical models
AU - Christiani, David C.
AU - Pao, William
AU - DeMartini, James C.
AU - Linnoila, R. Ilona
AU - Malkinson, Alvin M.
AU - Onn, Amir
AU - Politi, Katerina A.
AU - Sharp, Michael
AU - Kim, Kwok
PY - 2006/11
Y1 - 2006/11
N2 - INTRODUCTION: Human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC. This imprecise definition makes it difficult to perform epidemiologic analyses or to generate accurate animal models. However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative. METHODS/RESULTS: At the BAC Consensus Conference in 2004, our committee discussed issues relevant to BAC epidemiology, pathogenesis, and preclinical models. CONCLUSIONS: Elucidation of molecular events involved in BAC tumorigenesis will allow for more precise epidemiologic studies and improved animal models, which will enable development of more effective treatments against the disease.
AB - INTRODUCTION: Human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC. This imprecise definition makes it difficult to perform epidemiologic analyses or to generate accurate animal models. However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative. METHODS/RESULTS: At the BAC Consensus Conference in 2004, our committee discussed issues relevant to BAC epidemiology, pathogenesis, and preclinical models. CONCLUSIONS: Elucidation of molecular events involved in BAC tumorigenesis will allow for more precise epidemiologic studies and improved animal models, which will enable development of more effective treatments against the disease.
KW - Bronchioloalveolar carcinoma
KW - Epidemiology
KW - Lung cancer
KW - Pathogenesis
KW - Preclinical models
UR - http://www.scopus.com/inward/record.url?scp=34247844546&partnerID=8YFLogxK
U2 - 10.1016/s1556-0864(15)30002-2
DO - 10.1016/s1556-0864(15)30002-2
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C2 - 17409996
AN - SCOPUS:34247844546
SN - 1556-0864
VL - 1
SP - S2-S7
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 9 SUPPL.
ER -
