B-cell non-Hodgkin lymphoma linked to Coxiella burnetii

Clea Melenotte, Matthieu Million, Gilles Audoly, Audrey Gorse, Herve Dutronc, Gauthier Roland, Michal Dekel, Asuncion Moreno, Serge Cammilleri, Maria Patrizia Carrieri, Camelia Protopopescu, Philippe Ruminy, Hubert Lepidi, Bertrand Nadel, Jean Louis Mege, Luc Xerri, Didier Raoult

Research output: Contribution to journalArticlepeer-review

Abstract

Bacteria can induce human lymphomas, whereas lymphoproliferative disorders have been described in patients with Q fever. We observed a lymphoma in a patient with Q fever that prompted us to investigate the association between the 2 diseases. We screened 1468 consecutive patients of the 2004 to 2014 French National Referral Center for Q fever database. The standardized incidence ratios (SIRs) of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) were calculated comparatively to the 2012 Francim Registry. The presence of Coxiella burnetii was tested using immunofluorescence and fluorescence in situ hybridization using a specific 16S ribosomal RNA probe and genomic DNA probe. Seven patients (0.48%) presented mature B-cell lymphoma consisting of 6DLBCL and 1 FL. An excess risk of DLBCL and FL was found in Q fever patients compared with the general population (SIR [95% confidence interval], 25.4 [11.4-56.4] and 6.7 [0.9-47.9], respectively). C burnetii was detected in CD68+ macrophages within both lymphoma and lymphadenitis tissues but localization in CD123+plasmacytoid dendritic cells (pDCs) was found only in lymphoma tissues. Q fever patients with persistent focalized infection were found more at risk of lymphoma (hazard ratio, 9.35 [1.10-79.4]). Interleukin-10 (IL10) overproduction (P 5 .0003) was found in patients developing lymphoma. These results suggest that C burnetii should be added to the list of bacteria that promote human B-cell non-Hodgkin lymphoma ,possibly by the infection of pDCs andIL10 overproduction. Screening for early lymphoma diagnosis should be considered in the management of patients with Q fever, especially those with persistent focalized infections.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalBlood
Volume127
Issue number1
DOIs
StatePublished - 7 Jan 2016

Keywords

  • Coxiella burnetii is associated with an increased risk of lymphoma
  • Especially those with persistent focalized infections
  • Its presence in the tumor microenvironment may favor lymphomagenesis
  • Lymphoma has to be considered in patients with q fever and lymphoid disorders

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