B-cell lymphoma developing in the donor 9 years after donor-origin acute myeloid leukemia post bone marrow transplantation

B. Bielorai, H. J. Deeg, M. Weintraub, Y. Neumann, E. Rosner, N. Amariglio, G. Rechavi, A. Toren

Research output: Contribution to journalArticlepeer-review

Abstract

Donor-cell leukemia post bone marrow transplantation is a rare event. Most of the cases reported to date have developed in cells from an HLA-matched sibling, who had no evidence of malignant disease before or following the occurrence of donor-origin leukemia. We describe a 17-year-old female who developed B-cell lymphoma 9 years following the occurrence of donor-origin acute myeloid leukemia in her brother for whom she had donated marrow. Cytogenetic analysis of the tumor revealed multiple chromosomal aberrations. The donor was heterozygous for the Ashkenazi mutation of Bloom's syndrome, suggesting that donor-type leukemia could have resulted from genomic instability in the donor cells.

Original languageEnglish
Pages (from-to)931-934
Number of pages4
JournalBone Marrow Transplantation
Volume31
Issue number10
DOIs
StatePublished - May 2003

Keywords

  • Donor-origin leukemia
  • Genomic instability

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