Azathioprine-induced in vitro inhibition of prostaglandin E2 production by rabbit retina

S. Dottan; S. Glerstein; N. Naveh

doi:10.1016/0090-6980(87)90249-8

Azathioprine-induced in vitro inhibition of prostaglandin E₂ production by rabbit retina

S. Dottan^*, S. Glerstein, N. Naveh

^*Corresponding author for this work

Eye Institute (Goldschleger)

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Although much work exists concerning the clinical and immunosuppressive effects of azathioprine, little is known of the mechanism of action of this drug. The present study reports that azathioprine at the concentrations of 0.1 and 0.05 μg/ml causes a significant suppression of in vitro prostaglandin E₂ production by rabbit retinas. However, at concentrations below (0.01 μg/ml) or above (1,10 μ/ml) azathioprine was not inhibitory effect. These results suggest a dose-dependent inhibitory effect of azathioprine on prostaglandin E₂ production.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	Prostaglandins
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0090-6980(87)90249-8
State	Published - Aug 1987

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abstract = "Although much work exists concerning the clinical and immunosuppressive effects of azathioprine, little is known of the mechanism of action of this drug. The present study reports that azathioprine at the concentrations of 0.1 and 0.05 μg/ml causes a significant suppression of in vitro prostaglandin E2 production by rabbit retinas. However, at concentrations below (0.01 μg/ml) or above (1,10 μ/ml) azathioprine was not inhibitory effect. These results suggest a dose-dependent inhibitory effect of azathioprine on prostaglandin E2 production.",

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AB - Although much work exists concerning the clinical and immunosuppressive effects of azathioprine, little is known of the mechanism of action of this drug. The present study reports that azathioprine at the concentrations of 0.1 and 0.05 μg/ml causes a significant suppression of in vitro prostaglandin E2 production by rabbit retinas. However, at concentrations below (0.01 μg/ml) or above (1,10 μ/ml) azathioprine was not inhibitory effect. These results suggest a dose-dependent inhibitory effect of azathioprine on prostaglandin E2 production.

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Azathioprine-induced in vitro inhibition of prostaglandin E₂ production by rabbit retina

Abstract

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