Autonomic response during bladder hydrodistention in patients with bladder pain syndrome

Kobi Stav*, Erez Lang, Zacci Fanus, Dan Leibovici

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: We determined whether patients with bladder pain syndrome who have typical interstitial cystitis endoscopic findings, including glomerulations and/or Hunner ulcer, have a distinct autonomic response during bladder hydrodistention. Materials and Methods: Included in the study were 50 consecutive patients (40 females and 10 males) who met International Society for the Study of BPS recommendations. All patients underwent the same clinical evaluation, consisting of medical history, physical examination, urine and blood tests, urine cytology and culture, urinary tract ultrasound and urodynamics. Bladder hydrodistention and biopsies were performed using general anesthesia. Systolic and diastolic blood pressure, and heart rate were recorded after the induction of general anesthesia and at the end of the filling phase. Patients were divided into 2 groups, including patients with and without typical endoscopic findings, respectively. Clinical, histological and urodynamic variables, and autonomic parameters were compared between the 2 groups. Results: No significant differences in demographics, symptoms, pain severity, comorbidities, previous surgery, urodynamic variables, anesthetic bladder capacity or histological findings were found between the 2 groups. In patients with endoscopic findings average ± SD systolic and diastolic blood pressure increased by 25 ± 19 and 21 ± 12 mm Hg, respectively, and average heart rate increased by 12 ± 11 beats per minute. All hemodynamic changes were statistically significant (p <0.001). In patients without endoscopic findings a minor decrease in hemodynamic parameters was observed. Conclusions: Patients with bladder pain syndrome who have typical interstitial cystitis findings on endoscopy show a marked autonomic response during bladder hydrodistention, consisting of an increase in heart rate, and systolic and diastolic blood pressure.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalJournal of Urology
Issue number1
StatePublished - Jul 2012
Externally publishedYes


  • blood pressure
  • cystitis
  • heart rate
  • interstitial
  • pain
  • urinary bladder


Dive into the research topics of 'Autonomic response during bladder hydrodistention in patients with bladder pain syndrome'. Together they form a unique fingerprint.

Cite this