Autonomic nervous system derangement in fibromyalgia syndrome and related disorders

Hagit Cohen*, Lily Neumann, Moshe Kotler, Dan Buskila

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Fibromyalgia syndrome is a chronic, painful musculoskeletal disorder of unknown etiology and/or pathophysiology. During the last decade many studies have suggested autonomic nervous system involvement in this syndrome, although contradictory results have been reported. This review focuses on studies of the autonomic, nervous system in fibromyalgia syndrome and related disorders, such as chronic fatigue syndrome and irritable bowel syndrome on the one hand and anxiety disorder on the other, and highlights techniques of dynamic assessment of heart rate variability. It raises the potentially important prognostic implications of protracted autonomic dysfunction in patient populations with fibromyalgia and related disorders, especially for cardiovascular morbidty and mortality.

Original languageEnglish
Pages (from-to)755-760
Number of pages6
JournalIsrael Medical Association Journal
Issue number10
StatePublished - 2001
Externally publishedYes


  • Autonomic nervous system
  • Fibromyalgia syndrome
  • Heart rate variability
  • Orthostatic test
  • Power spectrum analysis


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