Autonomic impairment in essential hypertension in rats: Representation by a computerized model

O. Oz, G. Wasserman, S. Eliash, M. Ravid, S. Akselrod

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Additional insight is provided into autonomic blood pressure control in a normotensive vs. a hypertensive system, focusing on autonomic impairment as reflected in the time dependent heart-rate (HR) response to changes in arterial blood pressure (ABP). Three-month old, conscious, spontaneously hypertensive rats (SHR) were compared to their normotensive controls (WKY). In order to cause abrupt changes in ABP, multiple bolus injections of the vasoconstrictor phenylephrine and the vasodilator nitroprusside were administered. A computerized procedure based on peak detection from ABP, was used to obtain heart rate (HR) and mean systolic and diastolic ABP as a function of time after injection. The HR response to ▽ABP was observed at baseline as well as under vagal or β-sympathetic blockade. Gain and time delays of the various control limbs were extracted for each strain. Results indicate that WKY are capable to correct more effectively small and medium ABP changes, while SHR display a minimal HR response to small ABP changes but are capable of correcting large ABP increases.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Number of pages4
ISBN (Print)0818622253
StatePublished - May 1991
EventComputers in Cardiology - Proceedings - Chicago, IL, USA
Duration: 23 Sep 199026 Sep 1990

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574


ConferenceComputers in Cardiology - Proceedings
CityChicago, IL, USA


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