Autoimmunity in atherosclerosis: Lessons from experimental models

J. George, A. Afek, B. Gilburd, D. Harats, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

Abstract

The modern view of atherosclerosis is of a chronic inflammatory disorder. In accord with this paradigm, the process of uninhibited influx of fat to the vessel wall results from an 'adequate' response to various forms of injury (i.e. turbulence, infections, modified lipoproteins). This idea has been further extended by several groups, to assume that the atherosclerotic lesion can be the target of an autoimmune mediated attack. According to this hypothesis, the site of initiation of the plaque should bear/express the target autoantigen, whereas concomitantly a respective immune response is generated in the periphery. The examples illuminating this notion are β2GPI as a target autoantigen, HSP60/65 an oxidized-LDL. Herein we present evidence to support the involvement of autoimmune mechanisms in atherogenesis based on the experience from experimental models and human studies.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalLupus
Volume9
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Antiphospholipid antibodies
  • Atherosclerosis
  • Autoimmunity
  • HSP 60/65
  • OxLDL
  • β2-glycoprotein I

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