Autoimmunity-associated autonomic failure with sympathetic denervation

David S. Goldstein*, Courtney Holmes, Patti Sullivan, Vincenzo Donadio, Risa Isonaka, Elizabeth Zhong, Bobby Pourier, Steven Vernino, Irwin J. Kopin, Yehonatan Sharabi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We report a case of autoimmunity-associated autonomic failure in a young adult woman who developed arthritis followed 3 years later by pandysautonomia. There was early recovery of parasympathetic functions but persistent neurogenic orthostatic hypotension from post-ganglionic sympathetic denervation. Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalClinical Autonomic Research
Volume27
Issue number1
DOIs
StatePublished - 1 Feb 2017

Funding

FundersFunder number
National Institutes of Health
National Institute of Neurological Disorders and StrokeZIANS003034

    Keywords

    • Autoimmunity
    • Autonomic failure
    • Catecholamine
    • Norepinephrine
    • Sympathetic

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