Autoimmunity and schizophrenia: An epiphenomenon or an etiology?

H. Amital, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review


During the last 20 years considerable data have accumulated indicating that schizophrenia may have an autoimmune immunology. Patients with schizophrenia may have autoantibodies; in addition, cellular changes may occur that are compatible with autoimmunity, e.g., an increased number of CD5+ cells. If, indeed, schizophrenia does have an autoimmune pathogenesis, we should consider an alternative therapy based on immune system-manipulating drugs in addition to antipsychotic compounds.

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalIsrael Journal of Medical Sciences
Issue number9
StatePublished - 1993
Externally publishedYes


  • Autoantibodies
  • Autoimmunity
  • Brain
  • CD5+ cells
  • Schizophrenia


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