Autoimmune/inflammatory syndrome induced by adjuvants and thyroid autoimmunity

Abdulla Watad, Paula David, Stav Brown, Yehuda Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), presented by Shoenfeld and Agmon-Levin in 2011, is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants. Adjuvants are agents that entail the capability to induce immune reactions. Adjuvants are found in many vaccines and used mainly to increase the response to vaccination in the general population. Silicone has also been reported to be able to induce diverse immune reactions. Clinical cases and series of heterogeneous autoimmune conditions including systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis have been reported to be induced by several adjuvants. However, only a small number of cases of autoimmune thyroid disorder have been included under the umbrella of ASIA syndrome. Indeed, clinical cases of Hashimoto's thyroiditis and/or subacute thyroiditis were observed after the exposure to vaccines as well as silicone implantation. In our review, we aimed to summarize the current knowledge on ASIA syndrome presented as endocrinopathies, focusing on autoimmune thyroid disorders associated with the various adjuvants.

Original languageEnglish
Article number150
JournalFrontiers in Endocrinology
Issue numberJAN
StatePublished - 2017


  • Adjuvants
  • Autoimmune/inflammatory syndrome induced by adjuvants
  • Endocrinopathy
  • Graves disease
  • Hashimoto's thyroiditis
  • Silicone
  • Thyroid
  • Vaccines


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