Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk?

Idan Goren*, Gad Segal, Yehuda Shoenfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Silicone implants have been in use since the mid-twentieth century, especially in the field of reconstructive breast surgery, and have long been considered as biologically inert and harmless. However, growing body of evidence from the past two decades links silicone with subsequent autoimmunity-related complications, collectively known as autoimmune/inflammatory syndrome induced by adjuvant—ASIA. Previous data suggest that while some patients tend to develop post-exposure autoimmune phenomena such as ASIA, other do not. However, thus far, no criteria for risk stratification were suggested. This current review summarizes the data linking silicone implants and autoimmunity, suggesting means of defining individuals who are at increased risk to develop silicone-induced ASIA, and therefore, a recommendation was made to avoid silicone implantation, e.g., individuals with previously diagnosed autoimmune disorders or with genetic preponderance for hyperactive immune system should not be considered as candidates for silicone implantation.

Original languageEnglish
Pages (from-to)1661-1666
Number of pages6
JournalClinical Rheumatology
Issue number10
StatePublished - 26 Oct 2015


  • ASIA
  • Adjuvant
  • Autoimmune disease
  • Autoimmune/inflammatory syndrome induced by adjuvant
  • Autoimmunity
  • Relative risk
  • Silicone


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