@article{889a11c7a31a46a2a5a35c25750a4869,
title = "Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, β-Synuclein",
abstract = "Accumulating evidence suggests that autoimmunity against neuronal proteins is important for MS pathogenesis. We have characterized T- and B-cell responses associated with experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with recombinant β-Synuclein (βSync), a neuronal component. The encephalitogenic βSync-specific T cells recognize a single immunodominant region with an epitope delineated at amino acids 97-105; B-cell specificity is more widespread, albeit directed mostly to the C-terminus of βSync. Most interestingly, βSync-induced autoimmune T- and B-cell responses spread not only to other neuronal antigens but also to myelin encephalitogens, raising the possibility that anti-neuronal immune attacks could also result in demyelination.",
keywords = "Antigens/peptides/epitopes, Autoantibodies, Autoimmunity, Rodent, T cells",
author = "Neta Kela-Madar and {de Rosbo}, {Nicole Kerlero} and Ayal Ronen and Felix Mor and Avraham Ben-Nun",
note = "Funding Information: This work was supported in part by the Israel Science Foundation, the National Multiple Sclerosis Society of New York, the Israel Ministry of Health, the Estate of the Late Florence Blau, and the William Sahm Foundation. A. Ben-Nun is the incumbent of the Eugene and Marcia Applebaum Professorial Chair. The authors would like to thank Dr. L. Cohen for preparing βSync, Dr. M. Eisenstein for molecular modeling, and J. Oved for reading the manuscript for English expression. ",
year = "2009",
month = mar,
day = "31",
doi = "10.1016/j.jneuroim.2008.12.009",
language = "אנגלית",
volume = "208",
pages = "19--29",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier B.V.",
number = "1-2",
}