Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self β-synuclein

Felix Mor, Francisco Quintana, Avishai Mimran, Irun R. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

β-synuclein is a neuronal protein that accumulates in the plaques that characterize neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. It has been proposed that immunization to peptides of plaque-forming proteins might be used therapeutically to help dissociate pathogenic plaques in the brain. We now report that immunization of Lewis rats with a peptide from β-synuclein resulted in acute paralytic encephalomyelitis and uveitis. T cell lines and clones reactive to the peptide adoptively transferred the disease to naive rats. Immunoblotting revealed the presence of β-synuclein in heavy myelin, indicating that the expression of β-synuclein is not confined to neurons. These results add β-synuclein to the roster of encephalitogenic self Ags, point out the potential danger of therapeutic autoimmunization to β-synuclein, and alert us to the unsuspected possibility that autoimmunity to β-synuclein might play an inflammatory role in the pathogenesis of neurodegeneration.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalJournal of Immunology
Volume170
Issue number1
DOIs
StatePublished - 1 Jan 2003
Externally publishedYes

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