Autoimmune cholangiopathy associated with systemic lupus erythematosus

Samuel N. Heyman, Galia Spectre, Suhail Aamar, Dvora Rubinger, Orit Pappo, Zvi Ackerman

Research output: Contribution to journalArticlepeer-review


We report a 39-year-old female who presented over 11 years with autoimmune cholangiopathy associated with kaleidoscopic manifestations of systemic lupus erythematosus (SLE), including, arthritis, skin changes, pleuritis, diffuse proliferative glomerulonephritis, lymphadenopathy, splenomegaly, hyperglobulinemia, and major depression. While anti-mitochondrial antibodies (AMA) were absent, antinuclear (ANA) and anti-DNA antibodies were detected in high titres associated with hypocomplementemia. The patient also had vitamin B12 deficiency and antiphospholipid antibodies. The patient required steroids and repeated courses of cyclophosphamide for the management of lupus nephritis, and ursodeoxycholic acid (ursolite) administration resulted in amelioration of cholestatic laboratory abnormalities. This unusual case report and review of literature illustrate that immune liver disease may be an important clinical manifestation of SLE, especially autoimmune cholangiopathy.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
Issue number2
StatePublished - 2002
Externally publishedYes


  • Glomerulonephritis
  • Immune cholangiopathy
  • Liver
  • Pernicious anaemia
  • Primary biliary cirrhosis
  • Systemic lupus erythematosus


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