Autoimmune and inflammatory manifestations associated with acute myeloid leukemia with Trisomy 8—Case series and review of the literature

Shira Buchrits*, Dror Kozlovoski, Anat Gafter-Gvili, Pia Raanani, Lucille Hayman, Igor Revyako, Hanna Bernstine, Ofir Wolach, Shai Shimony

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

AML can be associated with autoimmune or inflammatory phenomena (AIP) occurring prior, concomitantly, or after its diagnosis. Trisomy 8 is one of the most common cytogenetic abnormalities associated with AML. We describe three patients with AML, trisomy 8, and associated AIP and review the known literature on this association. All of our patients had major symptomatic relief when treated with leukemia-directed therapy and corticosteroids. AIP in AML may be an underdiagnosed phenomenon, particularly in patients with trisomy 8.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalEuropean Journal of Haematology
Volume108
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • AML
  • Trisomy 8
  • autoimmune or inflammatory phenomena

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