Autocide AMI rescues development in dsg mutants of Myxococcus xanthus.

A. Rosenbluh*, E. Rosenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Low concentrations of autocide AMI rescued aggregation and sporulation in the dsg mutant class of Myxococcus xanthus but were incapable of rescuing asg, bsg, or csg mutants. AMI-induced spores of dsg mutants were resistant to heat and sonication and germinated when plated on nutrient-rich agar. AMI accelerated aggregation and sporulation and increased the final spore number in submerged cultures of a wild-type strain of M. xanthus. Development of M. xanthus was accompanied by release of a fluorescent material (emission maximum, 438 nm) into the supernatant fluid. The release of this material began early and continued throughout development. All Spo- mutant strains tested released significantly reduced levels of this material. These levels were increased in the presence of AMI in all Spo- mutant classes, most dramatically in the dsg mutants.

Original languageEnglish
Pages (from-to)1513-1518
Number of pages6
JournalJournal of Bacteriology
Issue number3
StatePublished - Mar 1989


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