TY - GEN
T1 - Autoantibody screen in inflammatory myopathies high prevalence of antibodies to gliadin
AU - Orbach, Hedi
AU - Amitai, Nimrod
AU - Barzilai, Ori
AU - Boaz, Mona
AU - Ram, Maya
AU - Zandman-Goddard, Gisele
AU - Shoenfeld, Yehuda
PY - 2009/9
Y1 - 2009/9
N2 - Background: Inflammatory myopathies (IM) are associated with autoimmune diseases. Aim: To evaluate the titers of auto-antibodies specific to various autoimmune diseases in patients with IM compared with controls. Methods: Sera from 99 IM patients and 100 healthy controls were tested for autoantibodies for vasculitis (myeloperoxidase, PR3, and glomerular basement membrane) and autoimmune gastrointestinal diseases (IgA and IgG antigliadin, antitissue transglutaminase, and Saccharomyces cerevisiae) utilizing the BioPlex 2200 Multiplexed Immunoassay method (Biorad). Results: Antigliadin IgA levels were significantly elevated in IM patients compared with controls (0.37 units ± 0.44 vs. 0.24 units ± 0.15, P = 0.017). Antitissue transglutaminase IgA was marginally increased in IM patients versus controls (0.36 units ± 1.12 vs. 0.2 units ± 0.0, P = 0.08). Conclusions: Antibodies to gliadin and tissue transglutaminase characteristic for celiac disease were elevated in patients with IM compared with controls. This may indicate a higher prevalence of gluten sensitivity or celiac disease in IM.
AB - Background: Inflammatory myopathies (IM) are associated with autoimmune diseases. Aim: To evaluate the titers of auto-antibodies specific to various autoimmune diseases in patients with IM compared with controls. Methods: Sera from 99 IM patients and 100 healthy controls were tested for autoantibodies for vasculitis (myeloperoxidase, PR3, and glomerular basement membrane) and autoimmune gastrointestinal diseases (IgA and IgG antigliadin, antitissue transglutaminase, and Saccharomyces cerevisiae) utilizing the BioPlex 2200 Multiplexed Immunoassay method (Biorad). Results: Antigliadin IgA levels were significantly elevated in IM patients compared with controls (0.37 units ± 0.44 vs. 0.24 units ± 0.15, P = 0.017). Antitissue transglutaminase IgA was marginally increased in IM patients versus controls (0.36 units ± 1.12 vs. 0.2 units ± 0.0, P = 0.08). Conclusions: Antibodies to gliadin and tissue transglutaminase characteristic for celiac disease were elevated in patients with IM compared with controls. This may indicate a higher prevalence of gluten sensitivity or celiac disease in IM.
KW - Antigliadin antibodies
KW - Antitissue transglutaminase antibodies
KW - Celiac disease
KW - Dermatomyositis
KW - Inclusion body myositis
KW - Inflammatory myopathies
KW - Polymyositis
UR - http://www.scopus.com/inward/record.url?scp=69949187961&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04810.x
DO - 10.1111/j.1749-6632.2009.04810.x
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C2 - 19758147
AN - SCOPUS:69949187961
SN - 9781573317627
T3 - Annals of the New York Academy of Sciences
SP - 174
EP - 179
BT - Contemporary Challenges in Autoimmunity
PB - Blackwell Publishing Inc.
ER -