TY - JOUR
T1 - Autoantibody-mediated atherosclerosis
AU - Matsuura, Eiji
AU - Kobayashi, Kazuko
AU - Koike, Takao
AU - Shoenfeld, Yehuda
PY - 2002/12
Y1 - 2002/12
N2 - β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by β2-GPI and anti-β2-GPI autoantibodies. Ligands specific for β2-GPI derived from oxLDL have been characterized as oxidized forms of cholesteryl linoleate, such as 7-ketocholesterol-9-carboxynonanoate, i.e. 9-oxo-9-(7-ketocholest-5-en-3β- yloxy) nonanoic acid, (namely oxLig-1). The in vitro phenomenon that it is significantly increased in binding of oxLig-1 containing liposomes to macrophages via an interaction with β2-GPI and an anti-β2-GPI autoantibody (via the Fcγ receptor) may propose a novel mechanism on 'autoantibody-mediated athrosclerosis'. Furthermore, autoantibodies against a complex of β2-GPI and oxLig-1 are detected in sera of APS patients and appearance of the antibodies is associated with episodes of thrombosis, especially, arterial thrombosis. Thus, autoimmune atherogenesis linked to β2-GPI interaction with oxLDL and autoantibodies may be present in APS.
AB - β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by β2-GPI and anti-β2-GPI autoantibodies. Ligands specific for β2-GPI derived from oxLDL have been characterized as oxidized forms of cholesteryl linoleate, such as 7-ketocholesterol-9-carboxynonanoate, i.e. 9-oxo-9-(7-ketocholest-5-en-3β- yloxy) nonanoic acid, (namely oxLig-1). The in vitro phenomenon that it is significantly increased in binding of oxLig-1 containing liposomes to macrophages via an interaction with β2-GPI and an anti-β2-GPI autoantibody (via the Fcγ receptor) may propose a novel mechanism on 'autoantibody-mediated athrosclerosis'. Furthermore, autoantibodies against a complex of β2-GPI and oxLig-1 are detected in sera of APS patients and appearance of the antibodies is associated with episodes of thrombosis, especially, arterial thrombosis. Thus, autoimmune atherogenesis linked to β2-GPI interaction with oxLDL and autoantibodies may be present in APS.
KW - Anti-β-glycoprotein I antibody
KW - Antiphospholipid syndrome
KW - Autoantibody
KW - Macrophage
KW - Oxidized LDL
KW - β-Glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=0037802819&partnerID=8YFLogxK
U2 - 10.1016/S1568-9972(02)00084-8
DO - 10.1016/S1568-9972(02)00084-8
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AN - SCOPUS:0037802819
SN - 1568-9972
VL - 1
SP - 348
EP - 353
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 6
ER -