Autoantibodies to DNA in multicase families with schizophrenia

Pinkhas Sirota*, Michael A. Firer, Klara Schild, Amir Tanay, Avner Elizur, Dina Meytes, Hanoch Slor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In an attempt to define the autoimmune status of members of multicase families with schizophrenia, sera of both patients and healthy relatives from 28 such cases were tested for antinuclear antibodies, anti-double-strandedDNA, and anti-single-strandedDNA autoantibodies. These autoantibodies were significantly more frequent in both schizophrenic patients and healthy relatives than in normal subjects. Immunoglobulin (Ig) M anti-DNA antibodies were more common in patients, whereas in healthy relatives, IgG anti-DNA antibodies were more common. No significant differences were found between schizophrenic patients and their healthy relatives. The data indicate that an autoimmune process may be involved in the etiology of a subset of patients with schizophrenia.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalBiological Psychiatry
Issue number6
StatePublished - 15 Mar 1993


  • Autoimmunity
  • DNA
  • autoantibodies
  • families
  • immunology
  • schizophrenia


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