TY - JOUR
T1 - Autoantibodies testing in autoimmunity
T2 - Diagnostic, prognostic and classification value
AU - Sciascia, Savino
AU - Bizzaro, Nicola
AU - Meroni, Pier Luigi
AU - Dimitrios, Bogdanos
AU - Borghi, Maria Orietta
AU - Bossuyt, Xavier
AU - Grossi, Claudia
AU - Tornai, Dávid
AU - Papp, Maria
AU - Shoenfeld, Yehuda
AU - Ielo, Daniele
AU - Fritzler, Marvin J.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/7
Y1 - 2023/7
N2 - Diagnosis of autoimmune diseases is in most cases challenging for clinicians as there is not a single specific laboratory or histological marker to diagnose or exclude the presence of the conditions. This review focused on the current knowledge of the role of autoantibodies' testing in various diseases, such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, undifferentiated connective tissues disease, primary biliary cholangitis and primary sclerosing cholangitis. Similarly, the prognostic and diagnostic values of autoantibodies testing in patients with interstitial lung disease have been reviewed. In-depth research on the molecular action of these autoantibodies on immune regulation and diseases pathogenesis has been explored beyond their correlation with disease phenotypes, highlighting the impact of autoantibodies targeting on disease outcomes and etiopathogenesis.
AB - Diagnosis of autoimmune diseases is in most cases challenging for clinicians as there is not a single specific laboratory or histological marker to diagnose or exclude the presence of the conditions. This review focused on the current knowledge of the role of autoantibodies' testing in various diseases, such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, undifferentiated connective tissues disease, primary biliary cholangitis and primary sclerosing cholangitis. Similarly, the prognostic and diagnostic values of autoantibodies testing in patients with interstitial lung disease have been reviewed. In-depth research on the molecular action of these autoantibodies on immune regulation and diseases pathogenesis has been explored beyond their correlation with disease phenotypes, highlighting the impact of autoantibodies targeting on disease outcomes and etiopathogenesis.
KW - Antiphospholipid syndrome
KW - Connective tissues disease
KW - Interstitial lung disease
KW - Primary biliary cirrhosis
KW - Rheumatoid arthritis
KW - Sclerosing cholangitis
UR - http://www.scopus.com/inward/record.url?scp=85159090024&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2023.103356
DO - 10.1016/j.autrev.2023.103356
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C2 - 37150488
AN - SCOPUS:85159090024
SN - 1568-9972
VL - 22
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 7
M1 - 103356
ER -
