Autoantibodies, idiotypes, anti-idiotypes and autoimmunity

D. Isenberg, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence of the common idiotypes as clinical activity marker was examined in patients with systemic lupus erythematosus. Based on Jerne's network theory [Ann. Immunol. 125c: 373-389, 1974], naturally occurring anti-idiotypic antibodies to anti-DNA antibodies were reported. The utilization of this information to understand autoimmunity is discussed.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalActa Haematologica
Issue number2-3
StatePublished - 1986
Externally publishedYes


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