Abstract
The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence of the common idiotypes as clinical activity marker was examined in patients with systemic lupus erythematosus. Based on Jerne's network theory [Ann. Immunol. 125c: 373-389, 1974], naturally occurring anti-idiotypic antibodies to anti-DNA antibodies were reported. The utilization of this information to understand autoimmunity is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 95-100 |
| Number of pages | 6 |
| Journal | Acta Haematologica |
| Volume | 76 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |