Audiological disturbances in patients with primary antiphospholipid syndrome

Daniel Erez, Eran Abarbuch, Amed Natour, Avraham Meyer, Aiman Natour, Zamir Dovrish, Yair Levy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Antiphospholipid syndrome (APS) is an autoimmune disease of hypercoagulability state in the presence of antibodies against phospholipids. Many neurological deficits related to APS have been described. Sensory neural hearing loss has been described only anecdotally, mostly in case reports. This study investigated a possible association between hearing disorders and APS. Methods: Seventeen patients (aged 20–80 years) diagnosed with primary APS were evaluated for evidence of hearing disorders. All had otoscopy, full audiometry test, brainstem evoked response audiometry and otoacoustic emissions testing, and completed a questionnaire. Hearing levels were compared to the standard hearing levels of the general population by age group. Results: Of the 17 APS patients, 10 (age groups 20–29 and 50–59) had significantly reduced hearing levels in all or part of the tested frequencies compared to standard levels. Three patients (age group 60–69) had better hearing levels at low frequencies compared to standard hearing levels. Conclusion: These findings support the existence of hearing disorders in primary APS.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
Issue number6
StatePublished - 1 May 2020


  • Antiphospholipid syndrome
  • audiological disturbances
  • hearing loss


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