Atypical fractures of the femur related to prolonged treatment with Bisphosphonates for osteoporosis

Yoav Rosenthal*, Amir Arami, Yona Kosashvili, Nir Cohen, Eli Sidon, Steven Velkes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphos-phonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft. objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment, and review the current literature. Conclusions: Despite the overall benefcial effect of bisphos-phonates, further research is required to prevent this signi-ficant complication.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalIsrael Medical Association Journal
Volume16
Issue number2
StatePublished - Feb 2014

Keywords

  • Atypical fracture
  • Bisphosphonates
  • Femur
  • Osteoporosis
  • Subtrochanteric fracture

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