Abstract
Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphos-phonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft. objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment, and review the current literature. Conclusions: Despite the overall benefcial effect of bisphos-phonates, further research is required to prevent this signi-ficant complication.
Original language | English |
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Pages (from-to) | 78-82 |
Number of pages | 5 |
Journal | Israel Medical Association Journal |
Volume | 16 |
Issue number | 2 |
State | Published - Feb 2014 |
Keywords
- Atypical fracture
- Bisphosphonates
- Femur
- Osteoporosis
- Subtrochanteric fracture