ATX restricts anti-tumor eosinophil responses

Sharon Grisaru-Tal, Ariel Munitz*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalNature Cancer
Volume5
Issue number2
DOIs
StatePublished - Feb 2024

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