Attenuation of Myelosuppression with Lithium

R. Catane, J. Kaufman, A. Mittelman, G. P. Murphy

Research output: Contribution to journalLetterpeer-review


To the Editor: Lithium causes granulocytosis by enhancing the production of colony-stimulating activity.1 Although in previous studies Tisman2 and Greco et al.3 suggested that patients receiving repeated courses of combination chemotherapy had less leukopenia with the addition of lithium carbonate, no randomized studies have been described. Ten patients with advanced hormone-resistant prostatic cancer treated with estramustine phosphate, 600 mg per square meter daily, and semustine (methyl-CCNU), 150 mg per square meter on the first day, were randomized to receive lithium carbonate or placebo. The first patients received 300 mg three times per day; later, the dose was reduced because of. No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)452-453
Number of pages2
JournalNew England Journal of Medicine
Issue number8
StatePublished - 25 Aug 1977


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