Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervation

Richard Imrich*, Basil A. Eldadah, Oladi Bentho, Sandra Pechnik, Yehonatan Sharabi, Courtney Holmes, David S. Goldstein

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Stress is a well-known factor affecting cardiac contractility through the cardiac sympathetic nerves. A positive inotropic effect of the cardiac sympathetic nerves on the myocardium is reflected by pre-ejection period (PEP) shortening. Patients with Parkinson disease (PD) and neurogenic orthostatic hypotension (NOH) (PD + NOH) or with pure autonomic failure (PAF) have markedly decreased myocardial 6-[18F]Fluorodopamine-derived radioactivity, reflecting cardiac sympathetic denervation. The functional effects of the cardiac sympathetic denervation have been unknown. We measured PEP and heart rate-corrected PEP (PEPI) responses to i.v. tyramine (1 mg/min) in 13 patients (9 PD + NOH and 4 PAF) with low 6-[18F]Fluorodopamine-derived radioactivity and in subjects with normal radioactivity (15 multiple system atrophy with NOS patients (MSA + NOS). Baseline PEP and PEPI did not differ between the groups. By 10 min after initiation of tyramine infusion, PEP and PEPI were significantly lower (P < 0.01) in MSA + NOS, compared to base line, whereas PEP and PEPI remained unchanged in the PD + NOH/PAF group. The PEP and PEPI decrease was larger in the MSA + NOS group than in the PD + NOH/PAF group (P < 0.05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release.

Original languageEnglish
Title of host publicationStress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms
PublisherBlackwell Publishing Inc.
Number of pages4
ISBN (Print)9781573316927
StatePublished - Dec 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


FundersFunder number
National Institute of Neurological Disorders and StrokeZIANS003034


    • Multiple system atrophy
    • Parkinson disease
    • Pre-ejection period
    • Pure autonomic failure
    • Sympathetic denervation


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