TY - JOUR
T1 - Attention deficit hyperactivity disorder in neurofibromatosis type 1
T2 - Evaluation with a continuous performance test
AU - Cohen, Rony
AU - Halevy, Ayelet
AU - Aharon, Sharon
AU - Shuper, Avinoam
N1 - Publisher Copyright:
© 2018 Korean Neurological Association.
PY - 2018/4
Y1 - 2018/4
N2 - Background and Purpose The objective of this study was to determine if the MOXO visual-and vocal-distractors-based continuous performance test distinguishes patients with attention deficit hyperactivity disorder (ADHD) and neurofibromatosis type 1 (NF1) from those without NF1. Methods Thirty-five patients (16 males; mean age 9.91 years) attending a multidisciplinary NF1 clinic completed the MOXO test. The findings were compared to 532 healthy age-matched standardized control subjects (285 males) without ADHD. Results The overall performance in the MOXO text was significantly worse in the NF1 group than in controls (p<0.01), but no group-specific pattern was identified. Impulsivity and hyperactivity were significantly more prominent in males than females (p<0.01). Compared to controls, the NF1 group exhibited significantly more failures to respond to target stimuli in the presence of visual distractors. Conclusions MOXO scores are abnormal in patients with NF1, but the test cannot differentiate between NF1 with ADHD characteristics and ADHD. The test highlights sex differences in ADHD characteristics in NF1. Overreactivity to visual distractors may form part of the attention deficit in NF1.
AB - Background and Purpose The objective of this study was to determine if the MOXO visual-and vocal-distractors-based continuous performance test distinguishes patients with attention deficit hyperactivity disorder (ADHD) and neurofibromatosis type 1 (NF1) from those without NF1. Methods Thirty-five patients (16 males; mean age 9.91 years) attending a multidisciplinary NF1 clinic completed the MOXO test. The findings were compared to 532 healthy age-matched standardized control subjects (285 males) without ADHD. Results The overall performance in the MOXO text was significantly worse in the NF1 group than in controls (p<0.01), but no group-specific pattern was identified. Impulsivity and hyperactivity were significantly more prominent in males than females (p<0.01). Compared to controls, the NF1 group exhibited significantly more failures to respond to target stimuli in the presence of visual distractors. Conclusions MOXO scores are abnormal in patients with NF1, but the test cannot differentiate between NF1 with ADHD characteristics and ADHD. The test highlights sex differences in ADHD characteristics in NF1. Overreactivity to visual distractors may form part of the attention deficit in NF1.
KW - Attention deficit hyperactivity disorder
KW - Continuous performance test
KW - MOXO
KW - Neurofibromatosis type 1
UR - http://www.scopus.com/inward/record.url?scp=85046479262&partnerID=8YFLogxK
U2 - 10.3988/jcn.2018.14.2.153
DO - 10.3988/jcn.2018.14.2.153
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AN - SCOPUS:85046479262
SN - 1738-6586
VL - 14
SP - 153
EP - 157
JO - Journal of Clinical Neurology (Korea)
JF - Journal of Clinical Neurology (Korea)
IS - 2
ER -