TY - JOUR
T1 - Atrial natriuretic peptide administration to normal and salt depleted rats - Effects on digoxin-like immunoreactive factor, aldosterone, acth, and renal function
AU - Shilo, L.
AU - Pomeranz, A.
AU - Rathaus, M.
AU - Weiss, E.
AU - Bernheim, J.
AU - Shenkman, L.
PY - 1988
Y1 - 1988
N2 - In view of the known interrelationships between renin, aldosterone, and atrial natriuretic peptide (ANP), we sought to examine whether there also exists an interaction between ANP and digoxin-like immunoreactive factor (DLIF). We therefore studied the effects of ANP administration on normal and salt-depleted rats, and measured the effects on blood pressure, urine output, glomerular filtration rate, sodium excretion, aldosterone, ACTH, and DLIF levels. ANP administration resulted in a significant elevation of sodium excretion and glomerular filtration rate and a fall in blood pressure. DLIF concentrations in plasma rose significantly, as did urinary DLIF excretion. ANP administration resulted in a fall in aldosterone as well as ACTH. These observations suggest that ANP has a direct inhibitory effect on ACTH secretion. Our findings support the concept of an interrelationship between ANP and DLIF.
AB - In view of the known interrelationships between renin, aldosterone, and atrial natriuretic peptide (ANP), we sought to examine whether there also exists an interaction between ANP and digoxin-like immunoreactive factor (DLIF). We therefore studied the effects of ANP administration on normal and salt-depleted rats, and measured the effects on blood pressure, urine output, glomerular filtration rate, sodium excretion, aldosterone, ACTH, and DLIF levels. ANP administration resulted in a significant elevation of sodium excretion and glomerular filtration rate and a fall in blood pressure. DLIF concentrations in plasma rose significantly, as did urinary DLIF excretion. ANP administration resulted in a fall in aldosterone as well as ACTH. These observations suggest that ANP has a direct inhibitory effect on ACTH secretion. Our findings support the concept of an interrelationship between ANP and DLIF.
UR - http://www.scopus.com/inward/record.url?scp=0023914658&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(88)90024-0
DO - 10.1016/0024-3205(88)90024-0
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AN - SCOPUS:0023914658
SN - 0024-3205
VL - 42
SP - 1855
EP - 1859
JO - Life Sciences
JF - Life Sciences
IS - 19
ER -