ATP-evoked membrane responses in Xenopus oocytes

Ilana Lotan, Nathan Dascal, Sasson Cohen, Yoram Lass*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Voltage-clamp technique and intracellular injections of drugs were used to study the adenosine triphosphate (ATP)-evoked depolarizing current response in the Xenopus laevis oocytes. The depolarizing current was comprised of a fast transient component (D1) followed by a late long-lasting component (D2). It was carried mainly by Cl- ions. The depolarizing current was better elicited by ATP and ADP than by AMP or adenosine and was not blocked either by theophylline (0.2 mM) or by quinidine sulphate (1 mM). The D2 current was sometimes masked by an ATP-evoked K+ hyperpolarizing current which was blocked by theophylline and mediated via P1 purinoceptors. This study suggests that the oocyte's membrane embodies at least two different purinoceptor's types, each of these types subserves a different set of ionic channels.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalPflugers Archiv European Journal of Physiology
Issue number2
StatePublished - Feb 1986


  • ATP
  • Oocyte
  • Purinoceptors


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