Atopy in children and adolescents with insulin-dependent diabetes mellitus

Vered Gazit, Diana Tasher, Aharon Hanukoglu, Zohar Landaú, Yoram Ben-Yehuda, Eli Somekh, Ilan Dalal

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Insulin-dependent diabetes mellitus is dominated by a Th1 response whereas atopic diseases such as asthma, eczema and allergic rhinitis are characterized by a Th2 response. Because it is known that Th1 and Th2 cells reciprocally counteract each other, it can be speculated that the prevalence of Th2-mediated diseases is lower in patients with a Th1-mediated disease. Objectives: To compare the prevalence of atopic diseases among children with IDDM and age-matched controls. Methods: The study group comprised 65 children with IDDM attending the pediatric endocrinology clinic at the Wolfson Medical Center. The control group consisted of 74 non-diabetic children who presented at the emergency room due to an acute illness (burns, abdominal pain, fever, head trauma). Patients were asked to complete a detailed questionnaire on their history of personal and familial atopic and autoimmune diseases. In addition, a total serum immunoglobulin E concentration and the presence of IgE antibodies to a panel of relevant inhalant allergens were analyzed. Results: Children with IDDM and their first-degree relatives had a significantly higher prevalence of other autoimmune diseases such as thyroiditis and celiac as compared to controls. The two groups had a similar prevalence of atopic diseases with respect to history, total serum IgE, or the presence of IgE antibodies to a panel of relevant inhalant allergens. Conclusions: The prevalence of atopic diseases in IDDM patients was similar to that in the normal population. Our results suggest that the traditional Th1/Th2 theory to explain the complexity of the immune response is oversimplified.

Original languageEnglish
Pages (from-to)858-861
Number of pages4
JournalIsrael Medical Association Journal
Volume10
Issue number12
StatePublished - Dec 2008

Keywords

  • Adolescents autoimmunity
  • Atopy
  • Children
  • Th1/Th2
  • Type I diabetes mellitus

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