Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues

Rajkumar Misra, Thangavel Vijayakanth, Linda J.W. Shimon, Lihi Adler-Abramovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary structure formation and the super helical assembly of two heptapeptides composed of sequential five and six phenylalanine (Phe) residues.

Original languageEnglish
Pages (from-to)6445-6448
Number of pages4
JournalChemical Communications
Volume58
Issue number44
DOIs
StatePublished - 12 May 2022

Funding

FundersFunder number
Horizon 2020 Framework Programme948102

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