TY - JOUR
T1 - ATM and related protein kinases
T2 - Safeguarding genome integrity
AU - Shiloh, Yosef
N1 - Funding Information:
The author wishes to thank the members of the David and Inez Myers Laboratory for Genetic Research for their dedication to A-T research. Work in the author’s laboratory is supported by research grants from the A-T Medical Research Foundation, The A-T Children’s Project, The A-T Medical Research Trust, The National Institutes of Health and the Israel Ministry of Science, Culture and Sport.
PY - 2003/3
Y1 - 2003/3
N2 - Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response - a cornerstone of genome stability - occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.
AB - Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response - a cornerstone of genome stability - occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.
UR - http://www.scopus.com/inward/record.url?scp=0037365789&partnerID=8YFLogxK
U2 - 10.1038/nrc1011
DO - 10.1038/nrc1011
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AN - SCOPUS:0037365789
SN - 1474-175X
VL - 3
SP - 155
EP - 168
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 3
ER -
