ATM and related protein kinases: Safeguarding genome integrity

Yosef Shiloh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2202 Scopus citations

Abstract

Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response - a cornerstone of genome stability - occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.

Original languageEnglish
Pages (from-to)155-168
Number of pages14
JournalNature Reviews Cancer
Volume3
Issue number3
DOIs
StatePublished - Mar 2003

Funding

FundersFunder number
A-T Medical Research Foundation
A-T Medical Research Trust
Israel Ministry of Science, Culture and Sport
National Institutes of Health

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