ATM and ATR: Networking cellular responses to DNA damage

Y. Shiloh

doi:10.1016/S0959-437X(00)00159-3

ATM and ATR: Networking cellular responses to DNA damage

Y. Shiloh^*

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Review article › peer-review

532 Scopus citations

Abstract

Maintenance of genome stability depends on the appropriate response to DNA damage. This response is based on complex networks of signaling pathways that activate numerous processes and lead ultimately to damage repair and cellular survival - or apoptosis. The protein kinases ATM and ATR are master controllers of some of these networks, acting either in concert or separately to orchestrate the responses to specific types of DNA damage or stalled replication. Understanding their mode of action is essential to our understanding of how cells cope with genotoxic stress.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(00)00159-3
State	Published - 1 Feb 2001

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10.1016/S0959-437X(00)00159-3

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ATM and ATR: Networking cellular responses to DNA damage

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