ATM and ATR: Networking cellular responses to DNA damage

Y. Shiloh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Maintenance of genome stability depends on the appropriate response to DNA damage. This response is based on complex networks of signaling pathways that activate numerous processes and lead ultimately to damage repair and cellular survival - or apoptosis. The protein kinases ATM and ATR are master controllers of some of these networks, acting either in concert or separately to orchestrate the responses to specific types of DNA damage or stalled replication. Understanding their mode of action is essential to our understanding of how cells cope with genotoxic stress.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - 1 Feb 2001


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