Atherosclerosis and autoimmunity

P. A. Gordon*, J. George, M. A. Khamashta, D. Harats, G. Hughes, Y. Shoenfeld

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In this article we explore the evidence for the role of autoimmunity in human atherosclerosis, both in the general population and in the context of the antiphospholipid syndrome. In particular we will focus on several autoantigens, review the evidence for their role in the process of atherosclerosis and the nature of the immune responses.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
Issue number4
StatePublished - 2001
Externally publishedYes


  • Heat shock protein
  • Hughes' Syndrome
  • Lipoprotein (a)
  • OxLDL


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