Atherosclerosis and Autoimmunity

C. Perricone, F. R. Spinelli, Y. Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Despite a decline in mortality rates in several countries, cardiovascular disease remains the leading cause of death responsible for approximately half of all deaths on the continent. Coronary artery disease and stroke are often the result of acute complications of atherosclerosis (AS) and atherothrombosis. AS is a chronic inflammatory disease, which may have an autoimmune background. Low-density lipoprotein infiltrates and accumulates in the intima of the arterial wall leading to an inflammatory process and the formation of atherosclerotic plaques. These contain lipids but also calcified and fibrotic tissue, vascular cells, cellular debris, and both innate and adaptive immune cells recruited into the arterial wall. When the disruption of an atherosclerotic lesion occurs, thrombus may develop leading to atherothrombosis.

Original languageEnglish
Title of host publicationHandbook of Systemic Autoimmune Diseases
PublisherElsevier Ltd.
Pages123-154
Number of pages32
DOIs
StatePublished - 2017

Publication series

NameHandbook of Systemic Autoimmune Diseases
Volume14
ISSN (Print)1571-5078

Keywords

  • AS
  • Atherosclerosis
  • HSP
  • Heat-shock protein
  • Oxidized LDL
  • oxLDL
  • β2-Glycoprotein-I
  • β2GPI

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