Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia

Aliza Amiel*, Tali Litmanovich, Elena Gaber, Michael Lishner, Lydia Avivi, Moshe D. Fejgin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalHuman Genetics
Issue number2
StatePublished - 1997


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