Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia

Aliza Amiel; Tali Litmanovich; Elena Gaber; Michael Lishner; Lydia Avivi; Moshe D. Fejgin

doi:10.1007/s004390050619

Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia

Aliza Amiel^*, Tali Litmanovich, Elena Gaber, Michael Lishner, Lydia Avivi, Moshe D. Fejgin

^*Corresponding author for this work

NY American Medicine Program

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.

Original language	English
Pages (from-to)	219-222
Number of pages	4
Journal	Human Genetics
Volume	101
Issue number	2
DOIs	https://doi.org/10.1007/s004390050619
State	Published - 1997

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abstract = "In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.",

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AU - Amiel, Aliza

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AU - Gaber, Elena

AU - Lishner, Michael

AU - Avivi, Lydia

AU - Fejgin, Moshe D.

PY - 1997

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AB - In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.

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Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia

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