Astemizole in perennial allergic rhinitis with seasonal exacerbations: A placebo-controlled double-blind study

A. Tanay, I. Neuman

Research output: Contribution to journalArticlepeer-review

Abstract

Astemizole is a nonsedative H1-antagonist. It was used in a randomized double-blind, placebo-controlled in-season trial to asses its efficacy in patients with perennial allergic rhinitis showing seasonal exacerbations. By the last (6th) week of the study, the mean overall symptomatology, as rated by a global composite score, was significantly mitigated in the astemizole-treated group (18 patients) compared with their first week's global composite score (P < .01). No such improvement was observed in the placebo-treated group (18 patients). Side effects were not appreciable throughout this short-term study. We conclude that astemizole is effective in the treatment of patients with perennial allergic rhinitis showing seasonal enhancement of symptoms.

Original languageEnglish
Pages (from-to)493-494
Number of pages2
JournalAnnals of Allergy
Volume63
Issue number6 I
StatePublished - 1989
Externally publishedYes

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