Associations of novel inflammatory markers with long-term outcomes and recurrence of diverticulitis

Yaniv Zager*, Nir Horesh, Assaf Dan, Mor Aharoni, Saed Khalilieh, Mordehay Cordoba, Avinoam Nevler, Mordechai Gutman, Danny Rosin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have emerged as markers of various outcomes of inflammatory and malignant diseases. The association of those markers with short-term outcomes of acute diverticulitis has been discussed in recent studies. This study aimed at evaluation of the association of NLR and PLR with long-term outcomes in patients presenting with acute diverticulitis. Methods: A retrospective single institute study included patients admitted with acute diverticulitis between 2012 and 2016. Associations were analysed of NLR and PLR values at admission with patient outcomes. Results: A total of 456 patients were included in the study. High NLR and PLR values were associated with complicated disease (P < 0.01 for both). Among patients with complicated diverticulitis, for those with high NLR, the interval to a recurrent episode of acute diverticulitis was shorter (68.3 days versus 83.7 days, P = 0.044). Patients with high NLR had higher mean number of readmissions (0.54 versus 0.34, P = 0.035). High NLR (10.06 ± 11.23 versus 7.6 ± 8.04, P = 0.012) and PLR (9.64 days ±10.56 versus 7.47 days ±8.225, P = 0.018) were associated with longer cumulative hospital stay due to acute diverticulitis. Conclusions: High NLR and PLR values were associated with recurrence in acute diverticulitis in terms of shorter interval between recurrent episodes and longer cumulative hospitalization days.

Original languageEnglish
Pages (from-to)2041-2045
Number of pages5
JournalANZ Journal of Surgery
Issue number10
StatePublished - 1 Oct 2020


  • diverticulitis
  • inflammatory marker
  • neutrophil-to-lymphocyte ratio
  • platelet-to-lymphocyte ratio
  • recurrence


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