Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

Meng Wang, Adeline Dehlinger, Camila Fernández Zapata, Maya Golan, Gerardina Gallaccio, Leif E. Sander, Stephan Schlickeiser, Desiree Kunkel, Tanja Schmitz-Hübsch, Birgit Sawitzki, Arnon Karni, Julian Braun, Lucie Loyal, Andreas Thiel, Judith Bellmann-Strobl, Friedemann Paul, Lil Meyer-Arndt, Chotima Böttcher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although these treatments are known to predispose patients to infections and affect their responses to vaccination, little is known about the impact of DMTs on the myeloid cell compartment. In this study, we use mass cytometry to examine DMT-associated changes in the innate immune system in untreated and treated patients with MS (n = 39) or NMOSD (n = 23). We also investigated the association between changes in myeloid cell phenotypes and longitudinal responsiveness to homologous primary, secondary, and tertiary SARS-CoV-2 mRNA vaccinations. Multiple DMT-associated myeloid cell clusters, in particular CD64+HLADRlow granulocytes, showed significant correlations with B and T cell responses induced by vaccination. Our findings suggest the potential role of myeloid cells in cellular and humoral responses following vaccination in DMT-treated patients with neuroimmunological diseases.

Original languageEnglish
Article number7728
JournalNature Communications
Volume14
Issue number1
DOIs
StatePublished - Dec 2023

Funding

FundersFunder number
Deutsche Forschungsgemeinschaft259373024
Bundesministerium für Gesundheit409525714, 2.1, CRU339
China Scholarship Council

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