Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts

Veronica Miller; Andrew N. Phillips; Bonaventura Clotet; Amanda Mocroft; Bruno Ledergerber; Ole Kirk; Vidar Ormaasen; Panagiotis Gargalianos-Kakolyris; Stefano Vella; Jens D. Lundgren; P. Hermans; B. Sommereijns; R. Colebunders; L. Machala; H. Rozsypal; J. Nielsen; J. Lundgren; T. Benfield; O. Kirk; J. Gerstoft; T. Katzenstein; B. Røge; P. Skinhøj; C. Pedersen; C. Katlama; C. Riviére; J. P. Viard; T. Saint-Marc; P. Vanhems; C. Pradier; M. Dietrich; C. Manegold; J. van Lunzen; V. Miller; S. Staszewski; F. D. Goebel; B. Salzberger; Jürgen Rockstroh; P. Gargalianos; H. Sambatakou; J. Perdios; G. Stergiou; G. Panos; G. Boulmetis; M. Astriti; D. Banhegyi; F. Mulcahy; I. Yust; D. Turner; S. Pollack; Z. Ben-Ishai; Z. Bentwich; S. Maayan; S. Vella; A. Chiesi; F. Suter; A. Cremaschi; P. Pristerá; F. Mazzotta; F. Vichi; B. DeRienzo; A. Bedini; A. Chirianni; V. Montesarchio; V. Vullo; P. Santopadre; C. Arrici; P. Franci; P. Narciso; A. Antinori; M. Zaccarelli; A. Lazzarin; R. Finazzi; A. D’arminio monforte; R. Colebunders; R. Hemmer; T. Staub; P. Reiss; J. Bruun; A. Mæland; V. Ormaasen; B. Knysz; J. Gasiorowski; A. Horban; R. Rogowska-Szadkowska; A. Boron-Kaczmarska; M. Beniowski; H. Trocha; F. Antunes; K. Mansinho; R. Proenca; J. González-Lahoz; R. Polo; V. Soriano; B. Clotet; A. Jou; J. Conejero; C. Tural; J. Gatell; J. Miró; A. Blaxhult; B. Heidemann; P. Pehrson; B. Ledergerber; R. Weber; A. Telenti; B. Hirschel; V. Soravia-Dunand; S. Barton; A. M. Johnson; D. Mercy; A. Phillips; C. Loveday; M. A. Johnson; A. Mocroft; D. Wilson; T. Drinkwater; A. Dykoff; D. Ross; A. Pinching; J. M. Parkin; J. Weber; D. Churchill; G. Scullard; M. Fisher; R. Brettle; J. Nielsen; N. Clumeck; M. Dietrich; J. M. Gatell; A. Horban; A. Johnson; C. Katlama; B. Ledergerber; C. Loveday; A. Phillips; P. Reiss; S. Vella; J. Lundgren; I. Gjørup; T. Benfield; O. Kirk; A. Mocroft; D. Mollerup; M. Nielsen; A. Sørensen; H. Buch; L. Teglbjçrg

doi:10.1086/341466

Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts

Veronica Miller, Andrew N. Phillips, Bonaventura Clotet, Amanda Mocroft, Bruno Ledergerber, Ole Kirk, Vidar Ormaasen, Panagiotis Gargalianos-Kakolyris, Stefano Vella, Jens D. Lundgren, P. Hermans, B. Sommereijns, R. Colebunders, L. Machala, H. Rozsypal, J. Nielsen, J. Lundgren, T. Benfield, O. Kirk, J. GerstoftT. Katzenstein, B. Røge, P. Skinhøj, C. Pedersen, C. Katlama, C. Riviére, J. P. Viard, T. Saint-Marc, P. Vanhems, C. Pradier, M. Dietrich, C. Manegold, J. van Lunzen, V. Miller, S. Staszewski, F. D. Goebel, B. Salzberger, Jürgen Rockstroh, P. Gargalianos, H. Sambatakou, J. Perdios, G. Stergiou, G. Panos, G. Boulmetis, M. Astriti, D. Banhegyi, F. Mulcahy, I. Yust, D. Turner, S. Pollack, Z. Ben-Ishai, Z. Bentwich, S. Maayan, S. Vella, A. Chiesi, F. Suter, A. Cremaschi, P. Pristerá, F. Mazzotta, F. Vichi, B. DeRienzo, A. Bedini, A. Chirianni, V. Montesarchio, V. Vullo, P. Santopadre, C. Arrici, P. Franci, P. Narciso, A. Antinori, M. Zaccarelli, A. Lazzarin, R. Finazzi, A. D’arminio monforte, R. Colebunders, R. Hemmer, T. Staub, P. Reiss, J. Bruun, A. Mæland, V. Ormaasen, B. Knysz, J. Gasiorowski, A. Horban, R. Rogowska-Szadkowska, A. Boron-Kaczmarska, M. Beniowski, H. Trocha, F. Antunes, K. Mansinho, R. Proenca, J. González-Lahoz, R. Polo, V. Soriano, B. Clotet, A. Jou, J. Conejero, C. Tural, J. Gatell, J. Miró, A. Blaxhult, B. Heidemann, P. Pehrson, B. Ledergerber, R. Weber, A. Telenti, B. Hirschel, V. Soravia-Dunand, S. Barton, A. M. Johnson, D. Mercy, A. Phillips, C. Loveday, M. A. Johnson, A. Mocroft, D. Wilson, T. Drinkwater, A. Dykoff, D. Ross, A. Pinching, J. M. Parkin, J. Weber, D. Churchill, G. Scullard, M. Fisher, R. Brettle, J. Nielsen, N. Clumeck, M. Dietrich, J. M. Gatell, A. Horban, A. Johnson, C. Katlama, B. Ledergerber, C. Loveday, A. Phillips, P. Reiss, S. Vella, J. Lundgren, I. Gjørup, T. Benfield, O. Kirk, A. Mocroft, D. Mollerup, M. Nielsen, A. Sørensen, H. Buch, L. Teglbjçrg

Research output: Contribution to journal › Article › peer-review

Abstract

This study prospectively assessed the impact of treatment modality, virus load, and CD4 cell count of <50 cells/mm³ on human immunodeficiency virus disease progression. The incidence rate of new AIDS disease or death was 54.8 (95% confidence interval, 48.7-59.9) per 100 person-years of follow-up. Independent predictors related to progression were latest CD4 cell count (relative risk [RR], 0.84/10 mm³ higher; P < .0001), latest hemoglobin level (RR, 0.79/g/L higher; P < .0001), Pneumocystis carinii pneumonia prophylaxis (RR, 0.49; P < .0001), latest body mass index (RR, 0.93/kg/m² higher; P = .002), latest virus load (RR, 1.11/log₁₀ higher; P = .03), and intensity of treatment (RR, 1.82, P = .004; RR 2.27, P < .0001; RR 2.46, P = .0001; RR 2.33 P < .0006;5.10, P < .0001, respectively, for 4, 3, 2, 1, or no drugs vs. ≥5 drugs). Although reverse causality cannot be excluded, more intense antiviral treatment appears to decrease the risk of progression in immunocompromised patients.

Original language	English
Pages (from-to)	189-197
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	186
Issue number	2
DOIs	https://doi.org/10.1086/341466
State	Published - 15 Jul 2002
Externally published	Yes

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10.1086/341466

Cite this

Miller, V., Phillips, A. N., Clotet, B., Mocroft, A., Ledergerber, B., Kirk, O., Ormaasen, V., Gargalianos-Kakolyris, P., Vella, S., Lundgren, J. D., Hermans, P., Sommereijns, B., Colebunders, R., Machala, L., Rozsypal, H., Nielsen, J., Lundgren, J., Benfield, T., Kirk, O., ... Teglbjçrg, L. (2002). Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts. Journal of Infectious Diseases, 186(2), 189-197. https://doi.org/10.1086/341466

Miller, Veronica ; Phillips, Andrew N. ; Clotet, Bonaventura ; Mocroft, Amanda ; Ledergerber, Bruno ; Kirk, Ole ; Ormaasen, Vidar ; Gargalianos-Kakolyris, Panagiotis ; Vella, Stefano ; Lundgren, Jens D. ; Hermans, P. ; Sommereijns, B. ; Colebunders, R. ; Machala, L. ; Rozsypal, H. ; Nielsen, J. ; Lundgren, J. ; Benfield, T. ; Kirk, O. ; Gerstoft, J. ; Katzenstein, T. ; Røge, B. ; Skinhøj, P. ; Pedersen, C. ; Katlama, C. ; Riviére, C. ; Viard, J. P. ; Saint-Marc, T. ; Vanhems, P. ; Pradier, C. ; Dietrich, M. ; Manegold, C. ; van Lunzen, J. ; Miller, V. ; Staszewski, S. ; Goebel, F. D. ; Salzberger, B. ; Rockstroh, Jürgen ; Gargalianos, P. ; Sambatakou, H. ; Perdios, J. ; Stergiou, G. ; Panos, G. ; Boulmetis, G. ; Astriti, M. ; Banhegyi, D. ; Mulcahy, F. ; Yust, I. ; Turner, D. ; Pollack, S. ; Ben-Ishai, Z. ; Bentwich, Z. ; Maayan, S. ; Vella, S. ; Chiesi, A. ; Suter, F. ; Cremaschi, A. ; Pristerá, P. ; Mazzotta, F. ; Vichi, F. ; DeRienzo, B. ; Bedini, A. ; Chirianni, A. ; Montesarchio, V. ; Vullo, V. ; Santopadre, P. ; Arrici, C. ; Franci, P. ; Narciso, P. ; Antinori, A. ; Zaccarelli, M. ; Lazzarin, A. ; Finazzi, R. ; D’arminio monforte, A. ; Colebunders, R. ; Hemmer, R. ; Staub, T. ; Reiss, P. ; Bruun, J. ; Mæland, A. ; Ormaasen, V. ; Knysz, B. ; Gasiorowski, J. ; Horban, A. ; Rogowska-Szadkowska, R. ; Boron-Kaczmarska, A. ; Beniowski, M. ; Trocha, H. ; Antunes, F. ; Mansinho, K. ; Proenca, R. ; González-Lahoz, J. ; Polo, R. ; Soriano, V. ; Clotet, B. ; Jou, A. ; Conejero, J. ; Tural, C. ; Gatell, J. ; Miró, J. ; Blaxhult, A. ; Heidemann, B. ; Pehrson, P. ; Ledergerber, B. ; Weber, R. ; Telenti, A. ; Hirschel, B. ; Soravia-Dunand, V. ; Barton, S. ; Johnson, A. M. ; Mercy, D. ; Phillips, A. ; Loveday, C. ; Johnson, M. A. ; Mocroft, A. ; Wilson, D. ; Drinkwater, T. ; Dykoff, A. ; Ross, D. ; Pinching, A. ; Parkin, J. M. ; Weber, J. ; Churchill, D. ; Scullard, G. ; Fisher, M. ; Brettle, R. ; Nielsen, J. ; Clumeck, N. ; Dietrich, M. ; Gatell, J. M. ; Horban, A. ; Johnson, A. ; Katlama, C. ; Ledergerber, B. ; Loveday, C. ; Phillips, A. ; Reiss, P. ; Vella, S. ; Lundgren, J. ; Gjørup, I. ; Benfield, T. ; Kirk, O. ; Mocroft, A. ; Mollerup, D. ; Nielsen, M. ; Sørensen, A. ; Buch, H. ; Teglbjçrg, L. / Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 2. pp. 189-197.

@article{f96994ad63d74a149ed08a4a48906e99,

title = "Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts",

abstract = "This study prospectively assessed the impact of treatment modality, virus load, and CD4 cell count of <50 cells/mm3 on human immunodeficiency virus disease progression. The incidence rate of new AIDS disease or death was 54.8 (95% confidence interval, 48.7-59.9) per 100 person-years of follow-up. Independent predictors related to progression were latest CD4 cell count (relative risk [RR], 0.84/10 mm3 higher; P < .0001), latest hemoglobin level (RR, 0.79/g/L higher; P < .0001), Pneumocystis carinii pneumonia prophylaxis (RR, 0.49; P < .0001), latest body mass index (RR, 0.93/kg/m2 higher; P = .002), latest virus load (RR, 1.11/log10 higher; P = .03), and intensity of treatment (RR, 1.82, P = .004; RR 2.27, P < .0001; RR 2.46, P = .0001; RR 2.33 P < .0006;5.10, P < .0001, respectively, for 4, 3, 2, 1, or no drugs vs. ≥5 drugs). Although reverse causality cannot be excluded, more intense antiviral treatment appears to decrease the risk of progression in immunocompromised patients.",

author = "Veronica Miller and Phillips, {Andrew N.} and Bonaventura Clotet and Amanda Mocroft and Bruno Ledergerber and Ole Kirk and Vidar Ormaasen and Panagiotis Gargalianos-Kakolyris and Stefano Vella and Lundgren, {Jens D.} and P. Hermans and B. Sommereijns and R. Colebunders and L. Machala and H. Rozsypal and J. Nielsen and J. Lundgren and T. Benfield and O. Kirk and J. Gerstoft and T. Katzenstein and B. R{\o}ge and P. Skinh{\o}j and C. Pedersen and C. Katlama and C. Rivi{\'e}re and Viard, {J. P.} and T. Saint-Marc and P. Vanhems and C. Pradier and M. Dietrich and C. Manegold and {van Lunzen}, J. and V. Miller and S. Staszewski and Goebel, {F. D.} and B. Salzberger and J{\"u}rgen Rockstroh and P. Gargalianos and H. Sambatakou and J. Perdios and G. Stergiou and G. Panos and G. Boulmetis and M. Astriti and D. Banhegyi and F. Mulcahy and I. Yust and D. Turner and S. Pollack and Z. Ben-Ishai and Z. Bentwich and S. Maayan and S. Vella and A. Chiesi and F. Suter and A. Cremaschi and P. Prister{\'a} and F. Mazzotta and F. Vichi and B. DeRienzo and A. Bedini and A. Chirianni and V. Montesarchio and V. Vullo and P. Santopadre and C. Arrici and P. Franci and P. Narciso and A. Antinori and M. Zaccarelli and A. Lazzarin and R. Finazzi and {D{\textquoteright}arminio monforte}, A. and R. Colebunders and R. Hemmer and T. Staub and P. Reiss and J. Bruun and A. M{\ae}land and V. Ormaasen and B. Knysz and J. Gasiorowski and A. Horban and R. Rogowska-Szadkowska and A. Boron-Kaczmarska and M. Beniowski and H. Trocha and F. Antunes and K. Mansinho and R. Proenca and J. Gonz{\'a}lez-Lahoz and R. Polo and V. Soriano and B. Clotet and A. Jou and J. Conejero and C. Tural and J. Gatell and J. Mir{\'o} and A. Blaxhult and B. Heidemann and P. Pehrson and B. Ledergerber and R. Weber and A. Telenti and B. Hirschel and V. Soravia-Dunand and S. Barton and Johnson, {A. M.} and D. Mercy and A. Phillips and C. Loveday and Johnson, {M. A.} and A. Mocroft and D. Wilson and T. Drinkwater and A. Dykoff and D. Ross and A. Pinching and Parkin, {J. M.} and J. Weber and D. Churchill and G. Scullard and M. Fisher and R. Brettle and J. Nielsen and N. Clumeck and M. Dietrich and Gatell, {J. M.} and A. Horban and A. Johnson and C. Katlama and B. Ledergerber and C. Loveday and A. Phillips and P. Reiss and S. Vella and J. Lundgren and I. Gj{\o}rup and T. Benfield and O. Kirk and A. Mocroft and D. Mollerup and M. Nielsen and A. S{\o}rensen and H. Buch and L. Teglbj{\c c}rg",

note = "Funding Information: Received 30 November 2001; revised 19 March 2002; electronically published 3 July 2002. National and local guidelines were followed to obtain informed consent at participating study centers. Financial support: European Commission (BIOMED); GlaxoSmithKline, Roche, and Boehringer-Ingelheim (unrestricted); Swiss Federal Office for Education and Science (support of Swiss sites). a Present affiliation: George Washington University, School of Public Health and Human Services, Washington, DC. b Study group members are listed after the text. Reprints or correspondence: Dr. Veronica Miller, Forum for Collaborative HIV Research, George Washington University, School of Public Health and Health Services, 2021 K St. NW, Ste. 800, Washington, DC 20009 (ihovim@gwumc.edu).",

year = "2002",

month = jul,

day = "15",

doi = "10.1086/341466",

language = "אנגלית",

volume = "186",

pages = "189--197",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

Miller, V, Phillips, AN, Clotet, B, Mocroft, A, Ledergerber, B, Kirk, O, Ormaasen, V, Gargalianos-Kakolyris, P, Vella, S, Lundgren, JD, Hermans, P, Sommereijns, B, Colebunders, R, Machala, L, Rozsypal, H, Nielsen, J, Lundgren, J, Benfield, T, Kirk, O, Gerstoft, J, Katzenstein, T, Røge, B, Skinhøj, P, Pedersen, C, Katlama, C, Riviére, C, Viard, JP, Saint-Marc, T, Vanhems, P, Pradier, C, Dietrich, M, Manegold, C, van Lunzen, J, Miller, V, Staszewski, S, Goebel, FD, Salzberger, B, Rockstroh, J, Gargalianos, P, Sambatakou, H, Perdios, J, Stergiou, G, Panos, G, Boulmetis, G, Astriti, M, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Pollack, S, Ben-Ishai, Z, Bentwich, Z, Maayan, S, Vella, S, Chiesi, A, Suter, F, Cremaschi, A, Pristerá, P, Mazzotta, F, Vichi, F, DeRienzo, B, Bedini, A, Chirianni, A, Montesarchio, V, Vullo, V, Santopadre, P, Arrici, C, Franci, P, Narciso, P, Antinori, A, Zaccarelli, M, Lazzarin, A, Finazzi, R, D’arminio monforte, A, Colebunders, R, Hemmer, R, Staub, T, Reiss, P, Bruun, J, Mæland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Rogowska-Szadkowska, R, Boron-Kaczmarska, A, Beniowski, M, Trocha, H, Antunes, F, Mansinho, K, Proenca, R, González-Lahoz, J, Polo, R, Soriano, V, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, J, Miró, J, Blaxhult, A, Heidemann, B, Pehrson, P, Ledergerber, B, Weber, R, Telenti, A, Hirschel, B, Soravia-Dunand, V, Barton, S, Johnson, AM, Mercy, D, Phillips, A, Loveday, C, Johnson, MA, Mocroft, A, Wilson, D, Drinkwater, T, Dykoff, A, Ross, D, Pinching, A, Parkin, JM, Weber, J, Churchill, D, Scullard, G, Fisher, M, Brettle, R, Nielsen, J, Clumeck, N, Dietrich, M, Gatell, JM, Horban, A, Johnson, A, Katlama, C, Ledergerber, B, Loveday, C, Phillips, A, Reiss, P, Vella, S, Lundgren, J, Gjørup, I, Benfield, T, Kirk, O, Mocroft, A, Mollerup, D, Nielsen, M, Sørensen, A, Buch, H & Teglbjçrg, L 2002, 'Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts', Journal of Infectious Diseases, vol. 186, no. 2, pp. 189-197. https://doi.org/10.1086/341466

Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts. / Miller, Veronica; Phillips, Andrew N.; Clotet, Bonaventura; Mocroft, Amanda; Ledergerber, Bruno; Kirk, Ole; Ormaasen, Vidar; Gargalianos-Kakolyris, Panagiotis; Vella, Stefano; Lundgren, Jens D.; Hermans, P.; Sommereijns, B.; Colebunders, R.; Machala, L.; Rozsypal, H.; Nielsen, J.; Lundgren, J.; Benfield, T.; Kirk, O.; Gerstoft, J.; Katzenstein, T.; Røge, B.; Skinhøj, P.; Pedersen, C.; Katlama, C.; Riviére, C.; Viard, J. P.; Saint-Marc, T.; Vanhems, P.; Pradier, C.; Dietrich, M.; Manegold, C.; van Lunzen, J.; Miller, V.; Staszewski, S.; Goebel, F. D.; Salzberger, B.; Rockstroh, Jürgen; Gargalianos, P.; Sambatakou, H.; Perdios, J.; Stergiou, G.; Panos, G.; Boulmetis, G.; Astriti, M.; Banhegyi, D.; Mulcahy, F.; Yust, I.; Turner, D.; Pollack, S.; Ben-Ishai, Z.; Bentwich, Z.; Maayan, S.; Vella, S.; Chiesi, A.; Suter, F.; Cremaschi, A.; Pristerá, P.; Mazzotta, F.; Vichi, F.; DeRienzo, B.; Bedini, A.; Chirianni, A.; Montesarchio, V.; Vullo, V.; Santopadre, P.; Arrici, C.; Franci, P.; Narciso, P.; Antinori, A.; Zaccarelli, M.; Lazzarin, A.; Finazzi, R.; D’arminio monforte, A.; Colebunders, R.; Hemmer, R.; Staub, T.; Reiss, P.; Bruun, J.; Mæland, A.; Ormaasen, V.; Knysz, B.; Gasiorowski, J.; Horban, A.; Rogowska-Szadkowska, R.; Boron-Kaczmarska, A.; Beniowski, M.; Trocha, H.; Antunes, F.; Mansinho, K.; Proenca, R.; González-Lahoz, J.; Polo, R.; Soriano, V.; Clotet, B.; Jou, A.; Conejero, J.; Tural, C.; Gatell, J.; Miró, J.; Blaxhult, A.; Heidemann, B.; Pehrson, P.; Ledergerber, B.; Weber, R.; Telenti, A.; Hirschel, B.; Soravia-Dunand, V.; Barton, S.; Johnson, A. M.; Mercy, D.; Phillips, A.; Loveday, C.; Johnson, M. A.; Mocroft, A.; Wilson, D.; Drinkwater, T.; Dykoff, A.; Ross, D.; Pinching, A.; Parkin, J. M.; Weber, J.; Churchill, D.; Scullard, G.; Fisher, M.; Brettle, R.; Nielsen, J.; Clumeck, N.; Dietrich, M.; Gatell, J. M.; Horban, A.; Johnson, A.; Katlama, C.; Ledergerber, B.; Loveday, C.; Phillips, A.; Reiss, P.; Vella, S.; Lundgren, J.; Gjørup, I.; Benfield, T.; Kirk, O.; Mocroft, A.; Mollerup, D.; Nielsen, M.; Sørensen, A.; Buch, H.; Teglbjçrg, L.

In: Journal of Infectious Diseases, Vol. 186, No. 2, 15.07.2002, p. 189-197.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts

AU - Miller, Veronica

AU - Phillips, Andrew N.

AU - Clotet, Bonaventura

AU - Mocroft, Amanda

AU - Ledergerber, Bruno

AU - Kirk, Ole

AU - Ormaasen, Vidar

AU - Gargalianos-Kakolyris, Panagiotis

AU - Vella, Stefano

AU - Lundgren, Jens D.

AU - Hermans, P.

AU - Sommereijns, B.

AU - Colebunders, R.

AU - Machala, L.

AU - Rozsypal, H.

AU - Nielsen, J.

AU - Lundgren, J.

AU - Benfield, T.

AU - Kirk, O.

AU - Gerstoft, J.

AU - Katzenstein, T.

AU - Røge, B.

AU - Skinhøj, P.

AU - Pedersen, C.

AU - Katlama, C.

AU - Riviére, C.

AU - Viard, J. P.

AU - Saint-Marc, T.

AU - Vanhems, P.

AU - Pradier, C.

AU - Dietrich, M.

AU - Manegold, C.

AU - van Lunzen, J.

AU - Miller, V.

AU - Staszewski, S.

AU - Goebel, F. D.

AU - Salzberger, B.

AU - Rockstroh, Jürgen

AU - Gargalianos, P.

AU - Sambatakou, H.

AU - Perdios, J.

AU - Stergiou, G.

AU - Panos, G.

AU - Boulmetis, G.

AU - Astriti, M.

AU - Banhegyi, D.

AU - Mulcahy, F.

AU - Yust, I.

AU - Turner, D.

AU - Pollack, S.

AU - Ben-Ishai, Z.

AU - Bentwich, Z.

AU - Maayan, S.

AU - Vella, S.

AU - Chiesi, A.

AU - Suter, F.

AU - Cremaschi, A.

AU - Pristerá, P.

AU - Mazzotta, F.

AU - Vichi, F.

AU - DeRienzo, B.

AU - Bedini, A.

AU - Chirianni, A.

AU - Montesarchio, V.

AU - Vullo, V.

AU - Santopadre, P.

AU - Arrici, C.

AU - Franci, P.

AU - Narciso, P.

AU - Antinori, A.

AU - Zaccarelli, M.

AU - Lazzarin, A.

AU - Finazzi, R.

AU - D’arminio monforte, A.

AU - Colebunders, R.

AU - Hemmer, R.

AU - Staub, T.

AU - Reiss, P.

AU - Bruun, J.

AU - Mæland, A.

AU - Ormaasen, V.

AU - Knysz, B.

AU - Gasiorowski, J.

AU - Horban, A.

AU - Rogowska-Szadkowska, R.

AU - Boron-Kaczmarska, A.

AU - Beniowski, M.

AU - Trocha, H.

AU - Antunes, F.

AU - Mansinho, K.

AU - Proenca, R.

AU - González-Lahoz, J.

AU - Polo, R.

AU - Soriano, V.

AU - Clotet, B.

AU - Jou, A.

AU - Conejero, J.

AU - Tural, C.

AU - Gatell, J.

AU - Miró, J.

AU - Blaxhult, A.

AU - Heidemann, B.

AU - Pehrson, P.

AU - Ledergerber, B.

AU - Weber, R.

AU - Telenti, A.

AU - Hirschel, B.

AU - Soravia-Dunand, V.

AU - Barton, S.

AU - Johnson, A. M.

AU - Mercy, D.

AU - Phillips, A.

AU - Loveday, C.

AU - Johnson, M. A.

AU - Mocroft, A.

AU - Wilson, D.

AU - Drinkwater, T.

AU - Dykoff, A.

AU - Ross, D.

AU - Pinching, A.

AU - Parkin, J. M.

AU - Weber, J.

AU - Churchill, D.

AU - Scullard, G.

AU - Fisher, M.

AU - Brettle, R.

AU - Nielsen, J.

AU - Clumeck, N.

AU - Dietrich, M.

AU - Gatell, J. M.

AU - Horban, A.

AU - Johnson, A.

AU - Katlama, C.

AU - Ledergerber, B.

AU - Loveday, C.

AU - Phillips, A.

AU - Reiss, P.

AU - Vella, S.

AU - Lundgren, J.

AU - Gjørup, I.

AU - Benfield, T.

AU - Kirk, O.

AU - Mocroft, A.

AU - Mollerup, D.

AU - Nielsen, M.

AU - Sørensen, A.

AU - Buch, H.

AU - Teglbjçrg, L.

N1 - Funding Information: Received 30 November 2001; revised 19 March 2002; electronically published 3 July 2002. National and local guidelines were followed to obtain informed consent at participating study centers. Financial support: European Commission (BIOMED); GlaxoSmithKline, Roche, and Boehringer-Ingelheim (unrestricted); Swiss Federal Office for Education and Science (support of Swiss sites). a Present affiliation: George Washington University, School of Public Health and Human Services, Washington, DC. b Study group members are listed after the text. Reprints or correspondence: Dr. Veronica Miller, Forum for Collaborative HIV Research, George Washington University, School of Public Health and Health Services, 2021 K St. NW, Ste. 800, Washington, DC 20009 (ihovim@gwumc.edu).

PY - 2002/7/15

Y1 - 2002/7/15

N2 - This study prospectively assessed the impact of treatment modality, virus load, and CD4 cell count of <50 cells/mm3 on human immunodeficiency virus disease progression. The incidence rate of new AIDS disease or death was 54.8 (95% confidence interval, 48.7-59.9) per 100 person-years of follow-up. Independent predictors related to progression were latest CD4 cell count (relative risk [RR], 0.84/10 mm3 higher; P < .0001), latest hemoglobin level (RR, 0.79/g/L higher; P < .0001), Pneumocystis carinii pneumonia prophylaxis (RR, 0.49; P < .0001), latest body mass index (RR, 0.93/kg/m2 higher; P = .002), latest virus load (RR, 1.11/log10 higher; P = .03), and intensity of treatment (RR, 1.82, P = .004; RR 2.27, P < .0001; RR 2.46, P = .0001; RR 2.33 P < .0006;5.10, P < .0001, respectively, for 4, 3, 2, 1, or no drugs vs. ≥5 drugs). Although reverse causality cannot be excluded, more intense antiviral treatment appears to decrease the risk of progression in immunocompromised patients.

AB - This study prospectively assessed the impact of treatment modality, virus load, and CD4 cell count of <50 cells/mm3 on human immunodeficiency virus disease progression. The incidence rate of new AIDS disease or death was 54.8 (95% confidence interval, 48.7-59.9) per 100 person-years of follow-up. Independent predictors related to progression were latest CD4 cell count (relative risk [RR], 0.84/10 mm3 higher; P < .0001), latest hemoglobin level (RR, 0.79/g/L higher; P < .0001), Pneumocystis carinii pneumonia prophylaxis (RR, 0.49; P < .0001), latest body mass index (RR, 0.93/kg/m2 higher; P = .002), latest virus load (RR, 1.11/log10 higher; P = .03), and intensity of treatment (RR, 1.82, P = .004; RR 2.27, P < .0001; RR 2.46, P = .0001; RR 2.33 P < .0006;5.10, P < .0001, respectively, for 4, 3, 2, 1, or no drugs vs. ≥5 drugs). Although reverse causality cannot be excluded, more intense antiviral treatment appears to decrease the risk of progression in immunocompromised patients.

UR - http://www.scopus.com/inward/record.url?scp=0037099450&partnerID=8YFLogxK

U2 - 10.1086/341466

DO - 10.1086/341466

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0037099450

VL - 186

SP - 189

EP - 197

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts

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