Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts

Veronica Miller, Andrew N. Phillips, Bonaventura Clotet, Amanda Mocroft, Bruno Ledergerber, Ole Kirk, Vidar Ormaasen, Panagiotis Gargalianos-Kakolyris, Stefano Vella, Jens D. Lundgren, P. Hermans, B. Sommereijns, R. Colebunders, L. Machala, H. Rozsypal, J. Nielsen, J. Lundgren, T. Benfield, O. Kirk, J. GerstoftT. Katzenstein, B. Røge, P. Skinhøj, C. Pedersen, C. Katlama, C. Riviére, J. P. Viard, T. Saint-Marc, P. Vanhems, C. Pradier, M. Dietrich, C. Manegold, J. van Lunzen, V. Miller, S. Staszewski, F. D. Goebel, B. Salzberger, Jürgen Rockstroh, P. Gargalianos, H. Sambatakou, J. Perdios, G. Stergiou, G. Panos, G. Boulmetis, M. Astriti, D. Banhegyi, F. Mulcahy, I. Yust, D. Turner, S. Pollack, Z. Ben-Ishai, Z. Bentwich, S. Maayan, S. Vella, A. Chiesi, F. Suter, A. Cremaschi, P. Pristerá, F. Mazzotta, F. Vichi, B. DeRienzo, A. Bedini, A. Chirianni, V. Montesarchio, V. Vullo, P. Santopadre, C. Arrici, P. Franci, P. Narciso, A. Antinori, M. Zaccarelli, A. Lazzarin, R. Finazzi, A. D’arminio monforte, R. Colebunders, R. Hemmer, T. Staub, P. Reiss, J. Bruun, A. Mæland, V. Ormaasen, B. Knysz, J. Gasiorowski, A. Horban, R. Rogowska-Szadkowska, A. Boron-Kaczmarska, M. Beniowski, H. Trocha, F. Antunes, K. Mansinho, R. Proenca, J. González-Lahoz, R. Polo, V. Soriano, B. Clotet, A. Jou, J. Conejero, C. Tural, J. Gatell, J. Miró, A. Blaxhult, B. Heidemann, P. Pehrson, B. Ledergerber, R. Weber, A. Telenti, B. Hirschel, V. Soravia-Dunand, S. Barton, A. M. Johnson, D. Mercy, A. Phillips, C. Loveday, M. A. Johnson, A. Mocroft, D. Wilson, T. Drinkwater, A. Dykoff, D. Ross, A. Pinching, J. M. Parkin, J. Weber, D. Churchill, G. Scullard, M. Fisher, R. Brettle, J. Nielsen, N. Clumeck, M. Dietrich, J. M. Gatell, A. Horban, A. Johnson, C. Katlama, B. Ledergerber, C. Loveday, A. Phillips, P. Reiss, S. Vella, J. Lundgren, I. Gjørup, T. Benfield, O. Kirk, A. Mocroft, D. Mollerup, M. Nielsen, A. Sørensen, H. Buch, L. Teglbjçrg

Research output: Contribution to journalArticlepeer-review

Abstract

This study prospectively assessed the impact of treatment modality, virus load, and CD4 cell count of <50 cells/mm3 on human immunodeficiency virus disease progression. The incidence rate of new AIDS disease or death was 54.8 (95% confidence interval, 48.7-59.9) per 100 person-years of follow-up. Independent predictors related to progression were latest CD4 cell count (relative risk [RR], 0.84/10 mm3 higher; P < .0001), latest hemoglobin level (RR, 0.79/g/L higher; P < .0001), Pneumocystis carinii pneumonia prophylaxis (RR, 0.49; P < .0001), latest body mass index (RR, 0.93/kg/m2 higher; P = .002), latest virus load (RR, 1.11/log10 higher; P = .03), and intensity of treatment (RR, 1.82, P = .004; RR 2.27, P < .0001; RR 2.46, P = .0001; RR 2.33 P < .0006;5.10, P < .0001, respectively, for 4, 3, 2, 1, or no drugs vs. ≥5 drugs). Although reverse causality cannot be excluded, more intense antiviral treatment appears to decrease the risk of progression in immunocompromised patients.

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalJournal of Infectious Diseases
Volume186
Issue number2
DOIs
StatePublished - 15 Jul 2002
Externally publishedYes

Fingerprint

Dive into the research topics of 'Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts'. Together they form a unique fingerprint.

Cite this