TY - JOUR
T1 - Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways
AU - Frisch, A.
AU - Postilnick, D.
AU - Rockah, R.
AU - Michaelovsky, E.
AU - Postilnick, S.
AU - Birman, E.
AU - Laor, N.
AU - Rauchverger, B.
AU - Kreinin, A.
AU - Poyurovsky, M.
AU - Schneidman, M.
AU - Modai, I.
AU - Weizman, R.
N1 - Funding Information:
This work was supported in part by grants from the National Institute for Psychobiology in Israel and the Recanati Fund for Medical Research, Tel-Aviv University, Israel.
PY - 1999
Y1 - 1999
N2 - Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of about 15%. The importance of the genetic component is well accepted, but the mode of inheritance is complex and non-Mendellan. A line of evidence suggests the involvement of serotonin and dopamine neurotransmitters in the pathophysiology of depression. In the present study, 102 unipolar MDD patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (TPH), serotonin receptor 2A (HTR2A), serotonin receptor 2C (HTR2C), serotonin transporter promoter region (5-HTTLPR), dopamine receptor D4 (DRD4), dopamine transporter (DAT1) and catechol-O-methyl transferase (COMT)]. There were no statistical differences between MDD patients and healthy controls in the genotypic and allelic distribution of all polymorphisms investigated. Thus, our study does not support a major role for these polymorphisms in contributing to susceptibility to MDD, although it does not preclude minor effects.
AB - Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of about 15%. The importance of the genetic component is well accepted, but the mode of inheritance is complex and non-Mendellan. A line of evidence suggests the involvement of serotonin and dopamine neurotransmitters in the pathophysiology of depression. In the present study, 102 unipolar MDD patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (TPH), serotonin receptor 2A (HTR2A), serotonin receptor 2C (HTR2C), serotonin transporter promoter region (5-HTTLPR), dopamine receptor D4 (DRD4), dopamine transporter (DAT1) and catechol-O-methyl transferase (COMT)]. There were no statistical differences between MDD patients and healthy controls in the genotypic and allelic distribution of all polymorphisms investigated. Thus, our study does not support a major role for these polymorphisms in contributing to susceptibility to MDD, although it does not preclude minor effects.
KW - Catechol-O-methyl transferase (COMT)
KW - Dopamine D4 receptor (DRD4)
KW - Dopamine transporter (DAT1)
KW - Major depressive disorder (MDD)
KW - Serotonin receptor 2A (HTR2A)
KW - Serotonin receptor 2C (HTR2C)
KW - Serotonin transporter promoter region (5-HTTLPR)
KW - Tryptophan hydroxylase (TPH)
UR - http://www.scopus.com/inward/record.url?scp=0032871864&partnerID=8YFLogxK
U2 - 10.1038/sj.mp.4000536
DO - 10.1038/sj.mp.4000536
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C2 - 10483058
AN - SCOPUS:0032871864
SN - 1359-4184
VL - 4
SP - 389
EP - 392
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 4
ER -