Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage

Danuta Wasserman; Thomas Geijer; Marcus Sokolowski; Amos Frisch; Elena Michaelovsky; Abraham Weizman; Vsevolod Rozanov; Jerzy Wasserman

doi:10.1016/j.euroneuro.2006.08.006

Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage

Danuta Wasserman^*, Thomas Geijer, Marcus Sokolowski, Amos Frisch, Elena Michaelovsky, Abraham Weizman, Vsevolod Rozanov, Jerzy Wasserman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n = 85). Comparing the presence of SS with SL + LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (χ² = 9.054, df = 1, p = 0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.

Original language	English
Pages (from-to)	230-233
Number of pages	4
Journal	European Neuropsychopharmacology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.euroneuro.2006.08.006
State	Published - Feb 2007
Externally published	Yes

Keywords

Behavior
Polymorphism
Promotor
Serotonin
Suicide
Transporter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.euroneuro.2006.08.006

Cite this

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title = "Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage",

abstract = "Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n = 85). Comparing the presence of SS with SL + LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (χ2 = 9.054, df = 1, p = 0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.",

keywords = "Behavior, Polymorphism, Promotor, Serotonin, Suicide, Transporter",

author = "Danuta Wasserman and Thomas Geijer and Marcus Sokolowski and Amos Frisch and Elena Michaelovsky and Abraham Weizman and Vsevolod Rozanov and Jerzy Wasserman",

note = "Funding Information: The authors would like to thank all interviewers at the Human Ecological Health Organization/Odessa National Mechnikov University, Odessa, Ukraine, for coordination of the material collection in Ukraine. The present study is a part of the Genetic Investigation of Suicide attempt and Suicide (GISS)-project which is funded by the Marianne and Marcus Wallenberg Foundation.",

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doi = "10.1016/j.euroneuro.2006.08.006",

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volume = "17",

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AU - Wasserman, Danuta

AU - Geijer, Thomas

AU - Sokolowski, Marcus

AU - Frisch, Amos

AU - Michaelovsky, Elena

AU - Weizman, Abraham

AU - Rozanov, Vsevolod

AU - Wasserman, Jerzy

N1 - Funding Information: The authors would like to thank all interviewers at the Human Ecological Health Organization/Odessa National Mechnikov University, Odessa, Ukraine, for coordination of the material collection in Ukraine. The present study is a part of the Genetic Investigation of Suicide attempt and Suicide (GISS)-project which is funded by the Marianne and Marcus Wallenberg Foundation.

PY - 2007/2

Y1 - 2007/2

N2 - Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n = 85). Comparing the presence of SS with SL + LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (χ2 = 9.054, df = 1, p = 0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.

AB - Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n = 85). Comparing the presence of SS with SL + LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (χ2 = 9.054, df = 1, p = 0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.

KW - Behavior

KW - Polymorphism

KW - Promotor

KW - Serotonin

KW - Suicide

KW - Transporter

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JO - European Neuropsychopharmacology

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ER -

Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage

Abstract

Keywords

UN SDGs

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