TY - JOUR
T1 - Association of serum relaxin with striae gravidarum in pregnant women
AU - Lurie, Samuel
AU - Matas, Zippora
AU - Fux, Asora
AU - Golan, Abraham
AU - Sadan, Oscar
N1 - Funding Information:
The study was partially supported by a Grant from the Israeli Society of Obstetrics and Gynecology in the Community.
PY - 2011/2
Y1 - 2011/2
N2 - Aims: The cause of striae gravidarum is still unclear. The study objective was to test the hypothesis that relaxin is involved in the process of striae gravidarum appearance during pregnancy. Methods: A prospective observational study in 32 pregnant women. Participants were observed at 12th, 24th and 36th gestational week. During each session, striae scoring was assessed and blood for relaxin estimation was withdrawn. The striae assessment was done according to Davey score. Serum relaxin was estimated using Relaxin ELISA kit (Immunodiagnostic AG, Bensheim, Germany). Results: Serum relaxin levels decreased as the pregnancy advanced (585.9 ± 295.1, 424.2 ± 253.8, 402.1 ± 221.2 pg/ml, respectively) but this decrease did not attain statistical significance. Pregnant women with striae gravidarum had lower serum relaxin levels compared to those without striae gravidarum at 36th gestational weeks, 330.8 ± 175.2 vs 493.8 ± 245.8 pg/ml (P = 0.037), respectively. The severity of striae gravidarum during pregnancy did not correlate with serum relaxin levels. Conclusion: Lower serum relaxin levels could contribute to the occurrence of striae gravidarum during pregnancy through decreased elasticity of the connective tissue.
AB - Aims: The cause of striae gravidarum is still unclear. The study objective was to test the hypothesis that relaxin is involved in the process of striae gravidarum appearance during pregnancy. Methods: A prospective observational study in 32 pregnant women. Participants were observed at 12th, 24th and 36th gestational week. During each session, striae scoring was assessed and blood for relaxin estimation was withdrawn. The striae assessment was done according to Davey score. Serum relaxin was estimated using Relaxin ELISA kit (Immunodiagnostic AG, Bensheim, Germany). Results: Serum relaxin levels decreased as the pregnancy advanced (585.9 ± 295.1, 424.2 ± 253.8, 402.1 ± 221.2 pg/ml, respectively) but this decrease did not attain statistical significance. Pregnant women with striae gravidarum had lower serum relaxin levels compared to those without striae gravidarum at 36th gestational weeks, 330.8 ± 175.2 vs 493.8 ± 245.8 pg/ml (P = 0.037), respectively. The severity of striae gravidarum during pregnancy did not correlate with serum relaxin levels. Conclusion: Lower serum relaxin levels could contribute to the occurrence of striae gravidarum during pregnancy through decreased elasticity of the connective tissue.
KW - Pregnancy
KW - Relaxin
KW - Striae gravidarum
UR - http://www.scopus.com/inward/record.url?scp=78751701628&partnerID=8YFLogxK
U2 - 10.1007/s00404-009-1332-5
DO - 10.1007/s00404-009-1332-5
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AN - SCOPUS:78751701628
SN - 0932-0067
VL - 283
SP - 219
EP - 222
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 2
ER -