Association of intentional changes in body weight with coronary heart disease event rates in overweight subjects who have an additional coronary risk factor

Sigal Eilat-Adar*, Michael Eldar, Uri Goldbourt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Despite evidence that weight loss improves the severity of coronary heart disease (CHD) risk factors, a direct association between weight loss and CHD incidence has not been demonstrated. In 1994-2001, the authors conducted an observational study of intentional weight loss as related to CHD incidence among patients recruited from a network of clinics in Israel who received nutritional counseling from a dietitian to support the medical recommendation to lose weight. Subjects were outpatients aged 50-75 years with a body mass index of ≥27 kg/m2, without CHD or cancer but with at least one risk factor for CHD in addition to overweight. Outcomes were documented over 4 years by repeated weight measurements and by medical record verification. Among 1,669 patients, 224 (13.4%) incidents of CHD were recorded. For subjects who underwent at least 6 months of dietetic counseling, the risk-factor-adjusted odds ratio for CHD incidence associated with a weight loss of 4.5 kg (the median level of weight loss) was 0.57 (95% confidence interval: 0.39, 0.84). In this, the largest known study of its type reported to date, intentional weight loss from a 6-month diet predicted lower incidence of CHD over 4 years.

Original languageEnglish
Pages (from-to)352-358
Number of pages7
JournalAmerican Journal of Epidemiology
Volume161
Issue number4
DOIs
StatePublished - 15 Feb 2005

Keywords

  • Body weight
  • Coronary disease
  • Counseling
  • Nutrition
  • Weight loss

Fingerprint

Dive into the research topics of 'Association of intentional changes in body weight with coronary heart disease event rates in overweight subjects who have an additional coronary risk factor'. Together they form a unique fingerprint.

Cite this