Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis

B. Schiff, Y. Mizrachi, S. Orgad, M. Yaron, E. Gazit

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-nine Israeli Jewish patients with rheumatoid arthritis (RA) were studied for their HLA, A, B, C, DR antigen frequency. A significant increase in HLA Aw31 and HLA DR1 was observed (p<5.10-3 respectively). 45% of Aw31 positive patients were seronegative for rheumatoid factor, while most HLA DR1 positive individuals were seropositive. DR5 was found to be significantly decreased (p<5.10-4). Contrary to previous reports, DRw4 was found to be within the range of antigen frequency of the controls (34.7% vs. 32%). It is suggested that in our population of patients Aw31 and DR1 and not DR4 are highly associated with adult onset of RA.

Original languageEnglish
Pages (from-to)403-404
Number of pages2
JournalUnknown Journal
Volume41
Issue number4
DOIs
StatePublished - 1982

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