Association of dopaminergic and serotonergic genes with tardive dyskinesia in patients with chronic schizophrenia

Ronen H. Segman*, T. Goltser, U. Heresco-Levy, B. Finkel, R. Shalem, M. Schlafman, A. Yakir, D. Greenberg, R. Strous, A. Lerner, A. Shelevoy, B. Lerer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drugs that are dopamine D2 receptor blockers. Serotonin receptor antagonism has been proposed as a common mechanism contributing to the low extrapyramidal side effect profile of atypical antipsychotic drugs. We evaluated candidate dopamine and serotonin genes for association with drug-induced TD. We examined three polymorphisms in the dopamine D2 receptor gene (DRD2), two sites in the 3′ region of the dopamine transporter (DAT) gene, two sites in the promoter and coding region of the dopamine D4 (DRD4) receptor gene, as well as polymorphic sites in the serotonin 6 receptor gene, the serotonin transporter gene and the tryptophan hydroxylase gene, for association with TD susceptibility. Schizophrenic patients with (n=59) and without TD (n=63), matched for antipsychotic drug exposure and other relevant variables, were studied. No significant associations were found. Within the limitations imposed by the size of the clinical sample, these findings suggest that the above polymorphic loci do not contribute significantly to risk for TD. Further examination of loci that yielded positive results at a trend level and investigation of other candidate genetic loci coding for antipsychotic drug targets is warranted.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalPharmacogenomics Journal
Issue number5
StatePublished - 2003
Externally publishedYes


FundersFunder number
Biological Psychiatry Laboratory
Hadassah Hebrew University Medical Center
Harry Stern Family Foundation
India–Israel Human Genome Research Project
National Institute for Psychobiology in Israel
Yisumi Fund of Hadassit Research and Development Corporation
National Alliance for Research on Schizophrenia and Depression


    • Dopamine
    • Genetic association
    • Serotonin
    • Tardive dyskinesia


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