Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children

Sandra Andorf, Magnus P. Borres, Whitney Block, Dana Tupa, Jennifer B. Bollyky, Vanitha Sampath, Arnon Elizur, Jonas Lidholm, Joseph E. Jones, Stephen J. Galli, Rebecca S. Chinthrajah, Kari C. Nadeau

Research output: Contribution to journalArticlepeer-review

Abstract

Background Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. Objective We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). Methods Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. Results Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. Conclusions Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut.

Original languageEnglish
Pages (from-to)1325-1334.e4
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume5
Issue number5
DOIs
StatePublished - Sep 2017
Externally publishedYes

Keywords

  • Component-resolved testing
  • Double-blind, placebo-controlled food challenge
  • IgE
  • Multifood allergy

Fingerprint

Dive into the research topics of 'Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children'. Together they form a unique fingerprint.

Cite this